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Conclusions under chapter 1

1) Rheumatic illnesses carry to group socially significant zabolevayony with which according to the international statistics 8,4 % of women and 5 % of men suffer. Development RZ causes a lesion of internal organs, that in sovokupyonosti with the basic implications of disease leads to an invalidism, to disability and life expectancy reduction.

2) For today the lupus erythematosus, a gout, a system scleroderma, juvenilnyj idiopaticheyosky an arthritis, syndrome SHegrena, spondylarthrites, rheumatic polimialgija, a rheumatic and system vasculitis is over 100 nosological forms RZ among which the greatest diffusion have a pseudorheumatism, sistemyonaja.

3) Etiology RZ has multifaktoryj character. Microcirculatory disturbances are an uniting link of a pathogenesis of all rheumatic zaboyolevany and can be shown in functioning failure reguljatornyh mechanisms of microvessels, disorders of microblood circulation and in architectural dezorgayonizatsii microvessels. Degree of an involvement of a microcirculatory bed in payotologichesky process in many respects defines a current and the forecast rheumatic boyolezni. Thus on a share of given extraarticular implications RZ 30-50 % of all morses are necessary.

4) Microcirculatory disturbances provoke occurrence soputstvuyojushchih complications which can lead to permeability deterioration memyobran for the oxygen, involving development of a hypoxia, edemas of tissues and pojavyolenie necrobiotic processes.

5) At revealing of microcirculatory disturbances it is important to estimate the general level of a blood flow in a microcirculatory bed, its regulation (fluctuations periyofericheskogo a blood flow), and also level of saturation of blood and tissues oxygen.

6) Now revealing of microcirculatory disturbances ograniyocheno owing to a small amount of tool methods of research. Also owing to difficulty of a simultaneous estimation of level of a blood flow in microcompasses - an even bed, mechanisms of regulation of a blood flow, level of saturation of blood and tissues oxygen, their application in a diagnostic arsenal of the doctor is ogranichenyonym. Besides, the expert estimation of probability of false-negative result of tool diagnostics by the given methods exceeds 0,3, while as much as possible admissible level of probability 0,2.

7) to Modern demands of applied medicine to the full udoyovletvorjajut methods of optical non-invasive diagnostics - laser dopplerovyoskaja flowmetry, an optical fabric oximetry and pulsioxymetry, thus their joint application allows to spend an estimation of fluctuations of a peripheric blood flow and a fabric saturation on the basis of which analysis of changes to do a conclusion about functioning reguljatornyh mechanisms and a condition of microcompasses - of an even bed.

8) For diagnostics of a microcirculatory bed, its estimation of the general sostojayonija, reserve and adaptive possibilities apply various funktsionalyonye assays. For revealing of microcirculatory disturbances at RZ the most preferable is holodovaja pressornaja assay which causes aktiyovatsiju sympathetic nervous system, indutsirovanie vasoconstrictions with posleyodujushchej vazodilatatsiej.

9) On the basis of the spent estimation of individual variability parayometrov a microcirculatory bed methods LDF, FROM and ON as area

90 researches the area of a distal phalanx of a long finger of a brush of the right arm which has the least disorder has been chosen. Besides, at development RZ from proceeding pathological processes fingers kiyostej arms that confirms the physiological importance of the given area issledoyovanija first of all suffer.

10) Preliminary researches with use of methods LDF, FROM and ON at carrying out HPP and an estimation of fluctuations of a peripheric blood flow and tkayonevoj saturations have shown high informativnost at the analysis of complex parametres of a microcirculatory bed, their reserve and adaptive vozmozhnoyostej, revealing of microcirculatory disturbances and accompanying them oslozhneyony, that is important at an estimation of pathogenesis RZ and consequently offered podyohod will be a basis of a developed method of diagnostics.

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Scientific source MAKOVIK Irina Nikolaevna. the METHOD And the DEVICE of DIAGNOSTICS of MICROCIRCULATORY DISTURBANCES AT RHEUMATIC DISEASES ON THE BASIS OF the VEJVLET-ANALYSIS of FLUCTUATIONS. The DISSERTATION on competition of a scientific degree of a Cand.Tech.Sci. of the PERIPHERIC BLOOD FLOW. Orel - 2018. 2018

Other medical related information Conclusions under chapter 1:

  1. Conclusions under chapter 1
  2. Conclusions under chapter 3
  3. Conclusions under chapter 1
  4. Conclusions under chapter 2
  5. Conclusions under chapter 4
  6. Conclusions under chapter 1
  7. Conclusions under chapter 2
  8. Conclusions under chapter 3
  9. CONCLUSIONS UNDER CHAPTER 1
  10. CONCLUSIONS UNDER CHAPTER 2
  11. CONCLUSIONS UNDER CHAPTER 3
  12. Conclusions under Chapter 1
  13. Conclusions under Chapter 2
  14. Conclusions under chapter 1
  15. Conclusions under chapter 2
  16. Conclusions under chapter 3
  17. Conclusions under chapter 1