THE TABLE OF CONTENTS
The list of reductions............................................................................................. 5
Introduction...............................................................................................................
7Chapter 1. The literature review................................................................................ 13
1.1 Modern representations about functional disorders
Intestine..................................................................................................... 13
1.2 Modern view on mechanisms of development of a syndrome angry
Intestine..................................................................................................... 16
1.2.1 Disturbance of an intestinal motility. Visceral
Hypersensitivity...................................................................................... 16
1.2.2 Visceral hypersensitivity of an intestine.............................. 18
1.2.3 Regulating system of an intestine............................................... 18
1.2.4 Estimation of a role of microbiological changes at a syndrome of an angry intestine. A syndrome of the superfluous
Bacteriemic growth......................................................................................... 20
1.2.5 Role of an infection in development SRK.................................................... 22
1.2.6 Inflammation at SRK..................................................................... 23
1.2.7 Chronic colitis at SRK........................................................ 25
1.3 Principles of treatment of children with SRK........................................................... 26
1.3.1 Correction of a motility..................................................................... 27
1.3.2 Correction disbioticheskih disturbances....................................... 29
1.3.3 Correction of inflammatory disturbances....................................... 30
1.3.4 Hypnotherapy. Kognitivno-behavioural therapy..................... 31
Chapter 2. Materials and research methods..................................................... 33
2.1 Clinical characteristic of groups...................................................... 33
2.2 Methods of research........................................................................... 35
2.2.1 Clinico-Anamnestichesky method of research........................... 35
2.2.2 Special methods of research............................................. 36
2.2.3 Traditional methods of inspection.......................................... 42
2.2 Methods of research............................................................................ 35
2.2.1 Clinico-Anamnestichesky method of research........................... 35
2.2.2 Special methods of research.............................................. 36
2.2.3 Traditional methods of inspection........................................... 42
2.3 Methods of the statistical analysis of results of research............... 43
Chapter 3. Clinical features of a syndrome of an angry intestine
At children............................................................................................................. 45
3.1 Structure of a syndrome of an angry intestine at children...................... 45
3.2 Clinico-Anamnestichesky features at children with SRK........................ 53
Chapter 4. Inflammatory changes in a colon mucosa at
Syndrome of an angry intestine at children.................................................... 70
4.1 Endoscopic picture of a colon at children with SRK..................... 70
4.2 Pathomorphologic features SRK at children................................. 74
4.3 Level of proinflammatory cytokines in SOTK at SRK................. 82
4.4 Level fecal kalprotektina at SRK..................................... 86
4.5 Visceral hypersensitivity at SRK................................. 90
Chapter 5. Changes intestinal mikrobioty at a syndrome of the angry
Intestine at children........................................................................................ 96
5.1 Change intestinal mikrobioty according to feces crops.................. 96
5.2 Syndrome of superfluous bacteriemic growth in a small bowel.......... 103
Chapter 6. A comparative estimation of efficiency of therapy of a syndrome
Angry intestine at children.............................................................. 112
6.1 Cupping of symptoms SRK.............................................................. 113
6.2 Change of level kalprotektina...................................................... 121
6.3 Change of indicators of the hydrogen respiratory test................. 123
6.4 Change of indicators intestinal mikrobioty after course of treatment. 130
6.5 Change of visceral hypersensitivity of a rectum..... 135
Chapter 7. Discussion of results of research............................................. 141
Conclusions............................................................................................................. 152
Practical references............................................................................. 153
The literature list............................................................................................ 154
The appendix....................................................................................................... 179
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