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THE TABLE OF CONTENTS

The list of reductions............................................................................................. 5

Introduction...............................................................................................................

7

Chapter 1. The literature review................................................................................ 13

1.1 Modern representations about functional disorders

Intestine..................................................................................................... 13

1.2 Modern view on mechanisms of development of a syndrome angry

Intestine..................................................................................................... 16

1.2.1 Disturbance of an intestinal motility. Visceral

Hypersensitivity...................................................................................... 16

1.2.2 Visceral hypersensitivity of an intestine.............................. 18

1.2.3 Regulating system of an intestine............................................... 18

1.2.4 Estimation of a role of microbiological changes at a syndrome of an angry intestine. A syndrome of the superfluous

Bacteriemic growth......................................................................................... 20

1.2.5 Role of an infection in development SRK.................................................... 22

1.2.6 Inflammation at SRK..................................................................... 23

1.2.7 Chronic colitis at SRK........................................................ 25

1.3 Principles of treatment of children with SRK........................................................... 26

1.3.1 Correction of a motility..................................................................... 27

1.3.2 Correction disbioticheskih disturbances....................................... 29

1.3.3 Correction of inflammatory disturbances....................................... 30

1.3.4 Hypnotherapy. Kognitivno-behavioural therapy..................... 31

Chapter 2. Materials and research methods..................................................... 33

2.1 Clinical characteristic of groups...................................................... 33

2.2 Methods of research........................................................................... 35

2.2.1 Clinico-Anamnestichesky method of research........................... 35

2.2.2 Special methods of research............................................. 36

2.2.3 Traditional methods of inspection.......................................... 42

2.2 Methods of research............................................................................ 35

2.2.1 Clinico-Anamnestichesky method of research........................... 35

2.2.2 Special methods of research.............................................. 36

2.2.3 Traditional methods of inspection........................................... 42

2.3 Methods of the statistical analysis of results of research............... 43

Chapter 3. Clinical features of a syndrome of an angry intestine

At children............................................................................................................. 45

3.1 Structure of a syndrome of an angry intestine at children...................... 45

3.2 Clinico-Anamnestichesky features at children with SRK........................ 53

Chapter 4. Inflammatory changes in a colon mucosa at

Syndrome of an angry intestine at children.................................................... 70

4.1 Endoscopic picture of a colon at children with SRK..................... 70

4.2 Pathomorphologic features SRK at children................................. 74

4.3 Level of proinflammatory cytokines in SOTK at SRK................. 82

4.4 Level fecal kalprotektina at SRK..................................... 86

4.5 Visceral hypersensitivity at SRK................................. 90

Chapter 5. Changes intestinal mikrobioty at a syndrome of the angry

Intestine at children........................................................................................ 96

5.1 Change intestinal mikrobioty according to feces crops.................. 96

5.2 Syndrome of superfluous bacteriemic growth in a small bowel.......... 103

Chapter 6. A comparative estimation of efficiency of therapy of a syndrome

Angry intestine at children.............................................................. 112

6.1 Cupping of symptoms SRK.............................................................. 113

6.2 Change of level kalprotektina...................................................... 121

6.3 Change of indicators of the hydrogen respiratory test................. 123

6.4 Change of indicators intestinal mikrobioty after course of treatment. 130

6.5 Change of visceral hypersensitivity of a rectum..... 135

Chapter 7. Discussion of results of research............................................. 141

Conclusions............................................................................................................. 152

Practical references............................................................................. 153

The literature list............................................................................................ 154

The appendix....................................................................................................... 179

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Scientific source TIPIKINA Maria Jurevna. ESTIMATION of the ROLE of INFLAMMATORY And MICROBIOLOGICAL CHANGES AT the SYNDROME of the ANGRY INTESTINE At CHILDREN. The dissertation on competition of a scientific degree of the candidate of medical sciences. St.-Petersburg - 2014. 2014

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