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THE TABLE OF CONTENTS

Introduction....................................................................................................... 4

Chapter 1. The LITERATURE REVIEW..................................................................

10

1.1. Introduction............................................................................................... 10

1.2. Classification JUIA........................................................................... 10

1.3. An aetiology and pathogenesis JUIA............................................................... 12

1.4. Approaches to therapy JUIA.................................................................... 14

1.5. Infliksimab........................................................................................ 15

1.6. Etanertsept............................................................................................ 22

1.7. Abatatsept.............................................................................................. 28

1.8. Comparative efficiency and safety GIBP........................ 32

1.9. The conclusion........................................................................................... 38

Chapter 2. MATERIALS And METHODS.......................................................... 39

Chapter 3. RESULTS of OWN RESEARCH.

EFFICIENCY AND SAFETY GIBP...................................... 49

3.1. Efficiency and safety infliksimaba at children with JUIA.......... 49

3.2. Efficiency and safety etanertsepta at children with JUIA.............. 78

3.3. Efficiency and safety abatatsepta at children with JUIA................ 107

Chapter 4 EFFICIENCY And SAFETY GIBP COMPARISON. (INFLIKSIMABA, ETANERTSEPTA, ABATATSEPTA) At CHILDREN With JUIA 137

4.1. Efficiency and safety GIBP comparison (infliksimaba, etanertsepta

And abatatsepta) at children with system variant JUIA.................................. 137

4.2. Efficiency and safety GIBP comparison (infliksimaba, etanertsepta

And abatatsepta) at children with articulate variant JUIA................................... 148

Chapter 5. DISCUSSION............................................................................. 159

CONCLUSIONS.................................................................................................... 169

PRACTICAL REFERENCES...................................................... 171

THE LITERATURE LIST........................................................................... 172

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Scientific source Loskutova Olga Jurevna. Efficiency and safety of genno-engineering biological preparations (infliksimab, etanertsept, abatatsept) at children with various variants juvenilnogo an idiopathic arthritis. The DISSERTATION on competition of a scientific degree of the candidate of medical sciences. Moscow - 2014. 2014

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