THE TABLE OF CONTENTS
INTRODUCTION........................................................................................................... 4
CHAPTER 1. THE LITERATURE REVIEW...................................................................
101.1. Rheumatic diseases as model of chronic pathological process 10
1.1.1 Modern representations about a pathogenesis of rheumatic diseases...10
1.1.2 Pathology of immune supervision as a basis of a pathogenesis of the rheumatic
Diseases..................................................................................................... 12
1.1.3 Exogenous and internal causes as process triggers
Autoimmune inflammation............................................................................ 13
1.1.4 Age features of rheumatic diseases at children.
JUvenilnyj a pseudorheumatism: clinico-pathogenetic variants....... 15
1.2 Anemia at chronic illnesses............................................................... 22
1.2.1. Bases of a pathogenesis of an anaemia at chronic illnesses........................ 23
1.2.2. Anaemia diagnostics at chronic diseases........................... 34
1.2.3. Variants of therapy of an anaemia at chronic illnesses and them
Efficiency................................................................................................. 37
CHAPTER 2. MATERIALS AND RESEARCH METHODS........................ 41
2.1. Design of research, criteria of including and an exception,
Grouping of the surveyed................................................................................... 41
2.2. Research methods.................................................................................. 43
2.3. The description of the investigated files............................................................. 46
2.4. Conducting a database and statistical processing of a material.................... 49
CHAPTER 3. RESULTS OF RESEARCH............................................. 50
3.1. Prevalence and gravity of an anaemia at children with juvenilnym
Pseudorheumatism...................................................................................... 50
3.2. Clinico-laboratory indicators at children with juvenilnym
Pseudorheumatism...................................................................................... 53
3.3. An anaemia at standard methods of therapy juvenilnogo a pseudorheumatism 55
3.3.1. Correlation of laboratory indicators at children receiving
Standard therapy juvenilnogo a pseudorheumatism............................. 55
3.3.2. The factors defining development of an anaemia at children with JURA,
Receiving standard therapy..................................................................... 56
3.4. Clinico-laboratory indicators at treatment of a chronic arthritis with
Use of biological therapy............................................................ 58
3.4.1. Correlation of clinico-laboratory indicators at children with JURA,
Receiving biological therapy................................................................ 58
3.4.2. The Clinico-laboratory indicators, allowing to define
Clinical form JURA at the patients receiving biological therapy 61
3.4.3. prediktory the answer to spent therapy....................................... 61
3.4.4. The Clinico-laboratory indicators, allowing to define a choice
Kind of biological therapy at patients with JURA............................................... 64
3.4.5. The Clinico-laboratory indicators defining level
Serumal gepsidina.................................................................................... 66
3.4.6. An average haemoglobin content in an erythrocyte - most
Sensitive controlled parametre.............................................................. 69
3.4.7. The analysis of three-dimensional models of dependence of concentration of haemoglobin
From various laboratory indicators........................................................... 73
3.5. An estimation of dynamics of average concentration of haemoglobin at children with JURA,
Receiving various variants of therapy......................................................... 75
THE CONCLUSION.................................................................................................. 78
CONCLUSIONS............................................................................................................ 85
PRACTICAL REFERENCES.......................................................... 86
THE LIST OF REDUCTIONS............................................................................... 87
THE LITERATURE LIST................................................................................. 89
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