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THE TABLE OF CONTENTS

INTRODUCTION........................................................................................................... 4

CHAPTER 1. THE LITERATURE REVIEW...................................................................

10

1.1. Rheumatic diseases as model of chronic pathological process 10

1.1.1 Modern representations about a pathogenesis of rheumatic diseases...10

1.1.2 Pathology of immune supervision as a basis of a pathogenesis of the rheumatic

Diseases..................................................................................................... 12

1.1.3 Exogenous and internal causes as process triggers

Autoimmune inflammation............................................................................ 13

1.1.4 Age features of rheumatic diseases at children.

JUvenilnyj a pseudorheumatism: clinico-pathogenetic variants....... 15

1.2 Anemia at chronic illnesses............................................................... 22

1.2.1. Bases of a pathogenesis of an anaemia at chronic illnesses........................ 23

1.2.2. Anaemia diagnostics at chronic diseases........................... 34

1.2.3. Variants of therapy of an anaemia at chronic illnesses and them

Efficiency................................................................................................. 37

CHAPTER 2. MATERIALS AND RESEARCH METHODS........................ 41

2.1. Design of research, criteria of including and an exception,

Grouping of the surveyed................................................................................... 41

2.2. Research methods.................................................................................. 43

2.3. The description of the investigated files............................................................. 46

2.4. Conducting a database and statistical processing of a material.................... 49

CHAPTER 3. RESULTS OF RESEARCH............................................. 50

3.1. Prevalence and gravity of an anaemia at children with juvenilnym

Pseudorheumatism...................................................................................... 50

3.2. Clinico-laboratory indicators at children with juvenilnym

Pseudorheumatism...................................................................................... 53

3.3. An anaemia at standard methods of therapy juvenilnogo a pseudorheumatism 55

3.3.1. Correlation of laboratory indicators at children receiving

Standard therapy juvenilnogo a pseudorheumatism............................. 55

3.3.2. The factors defining development of an anaemia at children with JURA,

Receiving standard therapy..................................................................... 56

3.4. Clinico-laboratory indicators at treatment of a chronic arthritis with

Use of biological therapy............................................................ 58

3.4.1. Correlation of clinico-laboratory indicators at children with JURA,

Receiving biological therapy................................................................ 58

3.4.2. The Clinico-laboratory indicators, allowing to define

Clinical form JURA at the patients receiving biological therapy 61

3.4.3. prediktory the answer to spent therapy....................................... 61

3.4.4. The Clinico-laboratory indicators, allowing to define a choice

Kind of biological therapy at patients with JURA............................................... 64

3.4.5. The Clinico-laboratory indicators defining level

Serumal gepsidina.................................................................................... 66

3.4.6. An average haemoglobin content in an erythrocyte - most

Sensitive controlled parametre.............................................................. 69

3.4.7. The analysis of three-dimensional models of dependence of concentration of haemoglobin

From various laboratory indicators........................................................... 73

3.5. An estimation of dynamics of average concentration of haemoglobin at children with JURA,

Receiving various variants of therapy......................................................... 75

THE CONCLUSION.................................................................................................. 78

CONCLUSIONS............................................................................................................ 85

PRACTICAL REFERENCES.......................................................... 86

THE LIST OF REDUCTIONS............................................................................... 87

THE LITERATURE LIST................................................................................. 89

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Scientific source EGOROV Andrey Sergeevich. THE GEPSIDIN-INTERLEUKIN-6 SYSTEM AS A FACTOR FOR MANAGING THE COURSE OF ANEMIA IN CHRONIC ARTHRITIS IN CHILDREN DISSERTATION for the degree of candidate of medical sciences. St. Petersburg - 2016. 2016

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