THE TABLE OF CONTENTS
The list of reductions | 4 | |
INTRODUCTION | 5 | |
CHAPTER 1. Modern representations about klinikoyoepidemiologicheskih, ethnogenetic features of a bronchial asthma at teenagers (the literature review) | 14 | |
1.1 Epidemiologija a bronchial asthma at teenagers: etnicheyoskie features | 14 | |
1.2 Bronchial asthma and a tobacco smoking | 20 | |
1.3 Genetic aspects of predisposition to a bronchial asthma and to formation of nicotinic dependence | 35 | |
1.4 Modern approaches to the analysis intergene and a gene-sredovyh of interactions at a bronchial asthma | 57 | |
CHAPTER 2. The characteristic of observable teenagers, volume and research methods | 66 | |
2.1 Ethnic characteristic of Aginsky Buryat district of Zayobajkalsky edge | 66 | |
2.2 Organization of epidemiological research («ISAAC») and a tobacco smoking among teenagers, a general characteristic obsledoyovannyh groups of teenagers, clinico-functional and laborayotornyh research methods | 67 | |
2.3 Molekuljarno-genetic methods of research | 74 | |
2.4. The statistical analysis | 77 | |
CHAPTER 3. Epidemiologija a bronchial asthma at teenagers, prozhiyovajushchih in a countryside of Transbaikalian edge: ethnic razliyochija | 79 | |
CHAPTER 4. The analysis of influence of a tobacco smoking on a current of a bronchial asthma at teenagers | 91 | |
4.1 Influence of a tobacco smoking on a current of a bronchial asthma at teenagers (according to clinico-epidemiological issledoyovanija) | 91 | |
4.2 Clinical features of a current of an exacerbation of a bronchial asthma at teenagers of Transbaikalia | 106 | |
CHAPTER 5. The analysis of the internal risk factors causing genetic predisposition to development of a bronchial asthma at teenagers in Transbaikalian edge | 120 |
5.1 Analysis of associations of polymorphisms of genes-candidates FCER2, ADRB2, TNFA, GSTM1, NOS2, NOS3, GSDMB c predraspolozhenyonostju to a bronchial asthma, change of clinico-laboratory parametres at the Buryat and the Russian living in Transbaikalian edge | 120 | |
5.2 Analysis of associations of genes-candidates of predisposition to tobacco smoking THOIи CHRNA5у sick of a bronchial asthma both healthy teenagers the Buryat and Russian | 138 | |
5.3 Modelling of intergene interactions at sick of a bronchial asthma the Buryat and the Russian living in Transbaikalian edge | 144 | |
5.4 Analysis of associations of genes-candidates of development of a bronchial asthma and predisposition to a tobacco smoking at the teenagers living in Transbaikalia: gender differences | 165 | |
CHAPTER 6. The analysis sochetannogo influences genetic and sredovyh factors contributing to a bronchial asthma (with the account mezhyogennyh interactions) | 174 | |
CHAPTER 7. Directions of aftertreatment of teenagers with a bronchial asthma | 193 | |
7.1 Substantiation of an orientation of antitobacco programs at kuyorjashchih teenagers with a bronchial asthma | 193 | |
7.2 Efficiency of application lizinovoj salts karbotsisteina in complex aftertreatment of teenagers with a bronchial asthma | 193 | |
7.3 Efficiency of application bosvellievyh acids in kompleksyonoj aftertreatments of teenagers with a bronchial asthma | 196 | |
THE CONCLUSION | 202 | |
CONCLUSIONS | 231 | |
PRACTICAL REFERENCES | 234 | |
THE LITERATURE LIST | 236 | |
APPENDICES | 278 |
Scientific source
BATOZHARGALOVA BAIRMA TSYDENDAMBAEVNA. CLINICO-EPIDEMIOLOGICAL, GENETIC And ETHNIC FEATURES of the BRONCHIAL ASTHMA At TEENAGERS of Transbaikalia. The dissertation on competition of a scientific degree of the doctor of medical sciences. Moscow - 2013. 2013
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