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THE TABLE OF CONTENTS

The list of reductions 4
INTRODUCTION 5
CHAPTER 1.
Modern representations about klinikoyoepidemiologicheskih, ethnogenetic features of a bronchial asthma at teenagers (the literature review)
14
1.1 Epidemiologija a bronchial asthma at teenagers: etnicheyoskie features 14
1.2 Bronchial asthma and a tobacco smoking 20
1.3 Genetic aspects of predisposition to a bronchial asthma and to formation of nicotinic dependence 35
1.4 Modern approaches to the analysis intergene and a gene-sredovyh of interactions at a bronchial asthma 57
CHAPTER 2. The characteristic of observable teenagers, volume and research methods 66
2.1 Ethnic characteristic of Aginsky Buryat district of Zayobajkalsky edge 66
2.2 Organization of epidemiological research (ISAAC) and a tobacco smoking among teenagers, a general characteristic obsledoyovannyh groups of teenagers, clinico-functional and laborayotornyh research methods 67
2.3 Molekuljarno-genetic methods of research 74
2.4. The statistical analysis 77
CHAPTER 3. Epidemiologija a bronchial asthma at teenagers, prozhiyovajushchih in a countryside of Transbaikalian edge: ethnic razliyochija 79
CHAPTER 4. The analysis of influence of a tobacco smoking on a current of a bronchial asthma at teenagers 91
4.1 Influence of a tobacco smoking on a current of a bronchial asthma at teenagers (according to clinico-epidemiological issledoyovanija) 91
4.2 Clinical features of a current of an exacerbation of a bronchial asthma at teenagers of Transbaikalia 106
CHAPTER 5. The analysis of the internal risk factors causing genetic predisposition to development of a bronchial asthma at teenagers in Transbaikalian edge 120

5.1 Analysis of associations of polymorphisms of genes-candidates FCER2, ADRB2, TNFA, GSTM1, NOS2, NOS3, GSDMB c predraspolozhenyonostju to a bronchial asthma, change of clinico-laboratory parametres at the Buryat and the Russian living in Transbaikalian edge 120
5.2 Analysis of associations of genes-candidates of predisposition to tobacco smoking THOIи CHRNA5у sick of a bronchial asthma both healthy teenagers the Buryat and Russian 138
5.3 Modelling of intergene interactions at sick of a bronchial asthma the Buryat and the Russian living in Transbaikalian edge 144
5.4 Analysis of associations of genes-candidates of development of a bronchial asthma and predisposition to a tobacco smoking at the teenagers living in Transbaikalia: gender differences 165
CHAPTER 6. The analysis sochetannogo influences genetic and sredovyh factors contributing to a bronchial asthma (with the account mezhyogennyh interactions) 174
CHAPTER 7. Directions of aftertreatment of teenagers with a bronchial asthma 193
7.1 Substantiation of an orientation of antitobacco programs at kuyorjashchih teenagers with a bronchial asthma 193
7.2 Efficiency of application lizinovoj salts karbotsisteina in complex aftertreatment of teenagers with a bronchial asthma 193
7.3 Efficiency of application bosvellievyh acids in kompleksyonoj aftertreatments of teenagers with a bronchial asthma 196
THE CONCLUSION 202
CONCLUSIONS 231
PRACTICAL REFERENCES 234
THE LITERATURE LIST 236
APPENDICES 278

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Scientific source BATOZHARGALOVA BAIRMA TSYDENDAMBAEVNA. CLINICO-EPIDEMIOLOGICAL, GENETIC And ETHNIC FEATURES of the BRONCHIAL ASTHMA At TEENAGERS of Transbaikalia. The dissertation on competition of a scientific degree of the doctor of medical sciences. Moscow - 2013. 2013

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