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THE TABLE OF CONTENTS

THE LIST OF REDUCTIONS AND DESIGNATIONS.......................................... 4

STATISTICS.......................................................... 5

INTRODUCTION........................................................................................................

6

CHAPTER 1. LITERARY DATA ON EARLY REVEALING OF THE TUBERCULOSIS AT CHILDREN AND TEENAGERS........................................... 11

1.1. Features of a tuberculosis at children and teenagers on the modern

Stage................................................................................................................... 11

1.2. Features of a tuberculinodiagnosis on a Mantoux reaction 2ТЕ in sovremenyonyh conditions 16

1.3. Diaskintestjv to diagnostics of a tubercular infection.............................. 21

CHAPTER 2. THE CHARACTERISTIC OF THE SURVEYED PATIENTS AND APPLIED METHODS OF INSPECTION..................................... 31

2.1. A general characteristic of the surveyed groups of patients........................ 31

2.2. Obshcheklinichesky methods......................................................................... 32

2.3. Laboratory methods............................................................................... 32

2.4. Dermal allergological assays in early diagnostics of a tuberculosis....33

2.5. Immunologic methods of research of blood serum................... 34

2.6. Methods of processing of the received results........................................... 35

CHAPTER 3. OWN RESULTS............................................. 36

3.1. The characteristic of group with for the first time taped clinical forms

tuberuleza.......................................................................................................... 36

3.2. The characteristic of group of children with revealing positive takes

Tuberculosis micobacteria................................................................................ 50

3.3. The characteristic of group of children with conversion tuberkulinovyh assays........ 55

3.4. Risk factors of development of a tubercular infection............................... 58

3.5. A clinical example.............................................................................. 64

3.6. Immunologic researches in studied groups......................... 69

3.6.1. Features of system of the general immunity and stimulirovannoj production

IFN-y In group of healthy children......................................................................... 69

3.6.2. Features of system of the general immunity and stimulirovannoj production

IFN-y At children with local forms of a tuberculosis.......................................... 72

3.6.3. Features of system of the general immunity and stimulirovannoj production

IFN-y At children with conversion tuberkulinovyh assays........................................... 78

3.6.4. The comparative analysis of immunologic indicators on

To groups........................................................................................................ 81

3.6.5. Features of subpopulation structure and stimulirovannoj production IFN-y at children with negative and positive takes with

Diaskintestj.................................................................................................... 84

CHAPTER 4. DISCUSSION............................................................................ 90

ALGORITHM OF DIAGNOSTICS................................................................... 102

CONCLUSIONS....................................................................................................... 103

PRACTICAL REFERENCES..................................................... 104

THE LIST OF THE USED REFERENCES.... 106

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Scientific source Ahmerova Tatyana Efimovna. IMMUNODIAGNOSIS OF DIFFERENT MANIFESTATIONS OF TUBERCULOSIS INFECTION IN CHILDREN. Thesis for the degree of candidate of medical sciences. SAMARA - 2014. 2014

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