the Pathology of immune supervision as a basis of a pathogenesis of rheumatic diseases

Rheumatic diseases are a typical example of multisystem autoimmune illnesses. T-limfotsity play crucial importance in development of autoimmune diseases. The understanding of their role in development of diseases has raised after the description of various subtypes CD4 + T-limfotsitov [76].

The leading part in development of rheumatic diseases is taken away to disturbance of balance T-limfotsitov, producing ИЛ-17 (Th17) and reguljatornyh T - lymphocytes (Treg) which function consists in maintenance of immune tolerance and counteraction to development of autoimmune diseases, by restraint autoreaktivnyh T-limfotsitov. Besides, Treg are of great importance for the control over inflammatory process, in maintenance of an immune hemostasis and prevention of autoimmune diseases [67,101,110,153,250].

Treg fenotipicheski and it is functional geterogenny and are presented both CD4 +, and CD8 + T-limfotsitami which most part express Foxp3 [67]. Treg also express antiinflammatory cytokines - ИЛ-10, transforming factor of growth in (TGF-0) and ИЛ-35, and also ingibitornye receptors - cytotoxic T-limfotsitarnyj an antigen 4 (CTLA4), a gene of activation of lymphocytes (LAG-3), a glucocorticoid-induced the factor of a necrosis of a tumour (GITR), CD39 and CD73 [214].

At people the H-bound genetic defect in Foxp3 which the syndrome of an immune dysregulation is a principal cause of the condition called , polyendocrinopathies, enteropathies (IPEX), shown by set of autoimmune disturbances [219] is defined. Less serious defects as Treg also have been put forward as the reason at several autoimmune diseases of the person. Functional insufficiency Foxp3 + Treg with depression or full absence on their surface CD25 is described
(Receptor ИЛ-2) at HARD CURRENCY [232]. Now there are more and more certificates of that defects as Treg assotsiirovany with RA. Quantity sinovialnoj Treg much more low at patients with long oligoartritom in comparison with their quantity at patients with softer current of disease [37]. Besides, larger quantity Treg was revealed in joints of patients RA in comparison with quantity in peripheric blood that specifies in enrichment Tregs in the inflamed joints [38]. However, apparently, that the big number reguljatornyh cells in a joint not in a condition to soften local inflammatory process. This fact can be bound to fastness effektornyh T cells and suppression or weakening in an inflammation place Treg - functions by local cytokines, such as ИЛ-6 [159,172]. Depression of maintenance Treg in blood of patients with a serious current of system form JURA [22] Besides, becomes perceptible.


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Scientific source EGOROV Andrey Sergeevich. THE GEPSIDIN-INTERLEUKIN-6 SYSTEM AS A FACTOR FOR MANAGING THE COURSE OF ANEMIA IN CHRONIC ARTHRITIS IN CHILDREN DISSERTATION for the degree of candidate of medical sciences. St. Petersburg - 2016. 2016

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