the Maintenance

INTRODUCTION............................................................................................................ 4

Chapter 1. The LITERATURE REVIEW.........................................................................

1.1. Epidemiologija chronic hepatitises at children and teenagers................. 16

1.2. A pathogenesis of chronic hepatitises.............................................................. 22

1.3. Patomorfologija chronic hepatitises at children and teenagers............... 30

1.4. Clinical implications of chronic hepatitises at children and teenagers. 35

1.5. The general principles of antiviral therapy of chronic hepatitises at children

And teenagers.................................................................................................... 56

1.6. Mediko-social problems of chronic hepatitises at children and

Teenagers....................................................................................................... 70

Chapter 2. MATERIALS And RESEARCH METHODS................................. 80

2.1 Material of research.............................................................................. 80

2.2 Methods of research................................................................................. 81

2.2.1. Epidemiological methods research............................................. 82

2.2.2. Laboratory methods of research........................................................ 82

2.2.3. Tool methods research................................................. 83

2.2.4. Research of quality of a life of children and teenagers with HG.......................... 84

2.2.5. Sociological research GSHS..................................................... 85

2.2.6. Statistical methods research....................................................... 86

Chapter 3 of FEATURE EPIDEMIOLOGII of CHRONIC VIRUS HEPATITISES At CHILDREN And TEENAGERS In REPUBLIC (Sakha) Yakutia 89

3.1. Prevalence of chronic virus hepatitises at children and teenagers in

RS ()..................................................................................................................... 89

3.2. The analysis of work of an office of the doctor-hepatologist.................................................. 98

3.3. The analysis of epidemiological given patients HG................................... 100

Chapter 4. CLINICO-LABORATORY HARKTERISTIKA CHRONIC HEPATITISES At CHILDREN And TEENAGERS..................................................... 113

4.1. Clinico-laboratonaja the characteristic of a chronic hepatitis In at children and teenagers............................................................................................................................ 113

4.2. Clinico-laboratonaja the characteristic of a chronic hepatitis With at children and

135

Teenagers

4.3. Clinico-laboratonaja the characteristic of chronic mikst-hepatitises at children and

152

Teenagers.................................................................................................

4.4. Quality of a life of children and teenagers with chronic hepatitises.....

Chapter 5. RESEARCH of EFFICIENCY ANTIVIRAL

THERAPIES OF CHRONIC HEPATITISES AT CHILDREN AND TEENAGERS... 174

5.1 Research of efficiency of antiviral therapy HGV at children and

175

168

Teenagers....................................................................................................

5.2 Research of efficiency of antiviral therapy HGS at children and

188

Teenagers...........................................................................................................

5.3 Forecasting of probability of effective antiviral therapy at HG a method logistical regressionnogo the analysis............................................................ 201

5.4. Forecasting of probability of conservation of effect of antiviral therapy at HG a method of the analysis of survival rate......................................................................... 205

Chapter 6. EPIDEMIOLOGICAL And RISK SOCIAL FACTORS ON INFECTION with VIRUS HEPATITISES At CHILDREN And TEENAGERS of of Yakutsk............................................................................................................................. 219

Chapter 7. The PROGRAM CONCEPT «CHRONIC HEPATITISES At CHILDREN

AND TEENAGERS »............................................................................................ 236

Chapter 8. The CONCLUSION

257

CONCLUSIONS........................................................................................................... 281

PRACTICAL REFERENCES............................................................ 284

THE LIST OF REDUCTIONS............................................................................... 287

THE LITERATURE LIST................................................................................. 289

APPENDICES

................................................................................................. 338