THE LITERATURE LIST

1. Clinical rheumatology (a management for doctors) / I.B.Beljaeva, E.G.Zotkin, N.A.Kunitsky, etc. [under the editorship of V.I.Mazurova]. - SPb., 2005. - 514 with.

2. Nasonov, E.L.immunopatholog of a pseudorheumatism and an osteoporosis: new data / E.L.Nasonov, D.A.Gukasjan, M.B.Nasonov//the Osteoporosis and osteopathies.

3. Nasonov, E.L.new aspects of application of cyclosporine And (Sandimmun) in rheumatology: treatment of a system lupus erythematosus / E.L.Nasonov, N.G.Kljukvina, S.V.Shekshina, V.A.Nasonov//Therapeutic archive. - 2000. - № 5. - with. 67-71.

4. Nasonov, E.L.antiinflammator therapy of rheumatic illnesses / E.L.Nasonov. - M, 1996. - 520 with.

5. Pauls, A.D.erythrogenes, erythropoetin, iron. Molecular and clinical aspects / A.D.Paul, E.F.Morshchakova, A.G.Rumjantsev. - M, 2011. - 304 with.

6. 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative / D. Aletaha, T. Neogi, A.J. Silman et al. / Arthritis Rheum. - 2010. - ³62 (9). - THE RIVER 2569-2581.

7. A ferroportin transcript that lacks an iron-responsive element enables duodenal and erythroid precursor cells to evade translational repression / D.L. Zhang, R.M. Hughes, H. Ollivierre-Wilson et al.//Cell Metab. - 2009. - № 9. - THE RIVER 461-473.

8. A novel SHP-1/Grb2-dependent mechanism of negative regulation of cytokine­receptor signalling: contribution of SHP-1 C-terminal tyrosines in cytokine signalling / P. Minoo, M.M. Zadeh, R. Rottapel et al.//Blood. - 2004. - №103. - THE RIVER 1398-1407.

9. A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression / R.H. Wang, C. Li X. Xu et al.//Cell Metab. - 2005. - №2. - THE RIVER 399-409.

10. Abnormalities in circulating plasmacytoid dendritic cells in patients with systemic lupus erythematosus / O. Jin, S. Kavikondala, M.Y. Mok et al.//Arthritis Research AND Therapy. - 2010. - Vol.12, №4. - R R137.

11. Adams, A. Update on the pathogenesis and treatment of systemic onset juvenile rheumatoid arthritis / A. Adams, T.J. Lehman//Curr Opin Rheumatol. - 2005. - №17. - P. 612-616.

12. Andrews, N.C. Anemia of inflammation: the cytokine-hepcidin link / N.C. Andrews//J Clin Invest. - 2004. - ³113 (9). - THE RIVER 1251-1253.

13. Andrews, N.C. The iron transporter DMT1 / N.C. Andrews//Int J Biochem Cell Biol. - 1999. - №31. - THE RIVER 991-994.

14. Anemia and blood transfusion in critically ill patients / J.L. Vincent, J.F. Baron,

K. Reinhart et al.//JAMA. - 2002. - №288. - THE RIVER 1499-1507.

15. Anti-citrullinated protein antibody (ACPA) in rheumatoid arthritis: influence of an interaction between HLA-DRB1 shared epitope and a deletion polymorphism in glutathione S-transferase in a cross-sectional study / T.R. Mikuls, K.A. Gould,

K.K. Bynote, et al.//Arthritis Res Ther. - 2010. - №12. - R R213.

16. Anticytokine treatment of established type II collagen-induced arthritis in DBA/1 mice: a comparative study using anti-TNFa, anti-IL-1a/e, and IL-1Ra / L.A.B. Joosten, M.M.A. Helsen, F.A.J. van de Loo, W.B. van den Berg//Arthritis Rheum. - 1996. - №39. - THE RIVER 797-809.

17. Association between serum inflammatory cytokines and disease activity in juvenile idiopathic arthritis / L.S.

18. Association between the PTPN22 gene and rheumatoid arthritis and juvenile idiopathic arthritis in an UK population: further support that PTPN22 is an autoimmunity gene / A. Hinks, A. Barton, S. John et al.//Arthritis Rheum. -

2005. - №52. - THE RIVER 1694-1699.

19. Association of anaemia and physical disability among patients with rheumatoid arthritis / C. Han, M.U. Rahman, M.K. Doyle et al.//J Rheumatol. - 2007. - ³34 (11). - THE RIVER 2177-2182.

20. Association of antigen specificity and migratory capacity of memory T cells in rheumatoid arthritis / K.R. Shadidi, K.M. Thompson, J.E. Henriksen et al.//Scand J Immunol. - 2002. - №55. - THE RIVER 274-283.

21. Association of HLA-B27 genetic polymorphisms with ankylosing spondylitis susceptibility worldwide: a meta-analysis / T. Yang, Z. Duan, S. Wu et al.//Mod Rheumatol. - 2014. - ³24 (1). - THE RIVER 150-161.

22. Autologous stem cell transplantation for autoimmunity induces immunologic self­tolerance by reprogramming autoreactive T cells and restoring the CD4+CD25 + immune regulatory network I. De Kleer, B. Vastert, M. Klein et al.//Blood. -

2006. - №107. - THE RIVER 1696-1702.

23. Barosi, G. Inadequate erythropoietin response to anaemia: definition and clinical relevance / G. Barosi//Ann Hematol. - 1994. - №68. - THE RIVER 215-223.

24. Bijlsma, J.W. Methotrexate: still the anchor drug in RA treatment / J.W. Bijlsma,

J.W. Jacobs//Joint Bone Spine. - 2009. - №76. - THE RIVER 452-454.

25. Biomarkers of inflammation in patients with unclassified polyarthritis and early rheumatoid arthritis. Relationship to disease activity and radiographic outcome /

L. S. Knudsen, M. Klarlund, H. Sk^dt et al.//J Rheumatol. - 2008. - №35. - THE RIVER 1277-1287.

26. Blood and synovial fluid cytokine signatures in patients with juvenile idiopathic arthritis: a cross-sectional study / W. De Jager, E.P. Hoppenreijs, N.M. Wulffraat et al.//Ann Rheum Dis. - 2007. - №66. - THE RIVER 589-598.

27. Body iron stores and the risk of cancer / R.G. Stevens, D.Y. Jones, M.S. Micozzi, P.R. Taylor//N Engl J Med. - 1988. - №319. - THE RIVER 1047-1052.

28. Body iron stores in relation to risk of type 2 diabetes in apparently healthy women / R. Jiang, J.E. Manson, J.B. Meigs et al.//JAMA. - 2004. - №291. - THE RIVER 711­717.

29. Boros, C. Juvenile idiopathic arthritis / C. Boros, B. Whitehead//Aust Fam Physician. 2010 ³39 (9). THE RIVER 630-636.

30. Brugnara, C. Iron deficiency and erythropoiesis: new diagnostic approaches / C. Brugnara//Clin Chem. - 2003. - №49. - THE RIVER 1573-1578.

31. Cachectin/tumor necrosis factor-alpha alters red blood cell kinetics and induces anaemia in vivo / L.L. Moldawer, M.A. Marano, H. Wei et al.//FASEB J. - 1989. - №3. - THE RIVER 1637-1643.

32. Camaschella, C. BMP6 orchestrates iron metabolism / C. Camaschella//Nat Genet. - 2009. - №41. - THE RIVER 386-388.

33. Camaschella, C. Iron and hepcidin: a story of recycling and balance / C. Camaschella//Hematology Am Soc Hematol Educ Program. - 2013. - THE RIVER 1-8.

34. Cartwright, G.E. The anaemia of chronic disorders / G.E. Cartwright, G.R. Lee//Br. J. Haematol. - 1971. - №21. - THE RIVER 147-152.

35. Cartwright, G.E. The anaemia of chronic disorders / G.E. Cartwright//Semin. Hematol. - 1966. - №3. - THE RIVER 351-375.

36. Cartwright, G.E. The anaemia of infection XVII. A review / G.E. Cartwright,

M.M. Wintrobe//Adv. Intern. Med. - 1952. - №5. - THE RIVER 165-226.

37. CD4+CD25bright regulatory T cells actively regulate inflammation in the joints of patients with the remitting form of juvenile idiopathic arthritis / I.M. De Kleer,

L. R. Wedderburn, L.S. Taams et al.//J Immunol. - 2004. - №172. - THE RIVER 6435­6443.

38. Coexpression of CD25 and CD27 identifies FoxP3 + regulatory T cells in inflamed synovia / C.R. Ruprecht, M. Gattorno, F. Ferlito et al.//J Exp Med. -

2005. - №201. - THE RIVER 1793-1803.

39. Contribution of interleukin 17 to synovium matrix destruction in rheumatoid arthritis / M. Chabaud, P. Garnero, J.M. Dayer et al.//Cytokine. - 2000. - №12. - THE RIVER 1092-1099.

40. Correlation of serum interleukin-6 levels with joint involvement and thrombocytosis in systemic juvenile rheumatoid arthritis / F. De Benedetti, M. Massa, P. Robbioni et al.//Arthritis Rheum. - 1991. - №34. - THE RIVER 1158-1163.

41. Cullis, J.O. Anaemia of chronic disease / J.O. Cullis//Clin Med. - 2013. - ³13 (2). - THE RIVER 193-196.

42. Cullis, J.O. Diagnosis and management of anaemia of chronic disease: current status / J.O. Cullis//Br J Haematol. - 2011. - ³154 (3). - THE RIVER 289-300.

43. Cytokine-mediated regulation of iron transport in human monocytic cells / S. Ludwiczek, E. Aigner I. Theurl, G. Weiss//Blood. - 2003. - №101. - THE RIVER 4148­4154.

44. Dallalio, G. Hepcidin inhibits in vitro erythroid colony formation at reduced erythropoietin concentrations / G. Dallalio, E. Law, R.T. Jr. Means//Blood. -

2006. - ³107 (7). - THE RIVER 2702-2704.

45. Decrease of interleukin 6 during the first 12 months is a prognostic marker for clinical outcome during 36 months treatment with disease-modifying
antirheumatic drugs / R.H. Straub, U. Muller-Ladner, T. Lichtinger et al.//Br J Rheumatol. - 1997. - №36. - THE RIVER 1298-1303.

46. Decreased erythropoietin response in patients with the anaemia of cancer / C.B. Miller, R.J. Jones, S. Piantadosi et al.//N Engl J Med. - 1990. - №322. - THE RIVER 1689-1692.

47. Defective iron supply to erythropoiesis and adequate endogenous erythropoietin production in the anaemia associated with systemic-onset juvenile chronic arthritis / M. Cazzola, L. Ponchio, F. De Benedetti et al.//Blood. - 1996. - №87. - THE RIVER 4824-4830.

48. Diagnostic potential of hepcidin testing in pediatrics / G. Cangemi, A. Pistorio,

M. Miano et al.//Eur J Haematol. - 2013. - ³90 (4). - THE RIVER 323-330.

49. Differences in synovial fluid cytokine levels between juvenile and adult rheumatoid arthritis / F. De Benedetti, P. Pignatti V. Gerloni et al.//J Rheumatol. - 1997. - №24. - THE RIVER 1403-1409.

50. Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate / R.N. Maini, P.C. Taylor, J. Szechinski et al.//Arthritis Rheum. - 2006. - №54. - THE RIVER 2817-2829.

51. Early activation of cutaneous vessels and epithelial cells is characteristic of acute systemic onset juvenile idiopathic arthritis / M. Frosch, D. Metze, D. Foell et al.//Exp Dermatol. - 2005. - №14. - THE RIVER 259-265.

52. Ebringer, A. HLA molecules, bacteria and autoimmunity / A. Ebringer, C. Wilson//J Med Microbiol. - 2000. - ³49 (4). - THE RIVER 305-311.

53. Effect of hepcidin on intestinal iron absorption in mice / A.H. Laftah, B. Ramesh, R.J. Simpson et al.//Blood. - 2004. - №103. - THE RIVER 3940-3944.

54. Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial / J.S. Smolen, A. Beaulieu, A. Rubbert-Roth et al.//Lancet. - 2008. - №371. - THE RIVER 987-997.

55. Effect of iron treatment on circulating cytokine levels in ESRD patients receiving recombinant human erythropoietin / G. Weiss, E. Meusburger, G. Radacher et al.//Kidney Int. - 2003. - №64. - THE RIVER 572-578.

56. Effect of recombinant human erythropoietin and intravenous iron on anaemia and disease activity in rheumatoid arthritis / J.P. Kaltwasser, U. Kessler, R. Gottschalk et al.//J Rheumatol. - 2001. - №28. - THE RIVER 2430-2436.

57. Elevation of proinflammatory cytokine (IL-18, IL-17, IL-12) and Th2 cytokine (IL-4) concentrations in patients with systemic lupus erythematosus / C.K. Wong, C.Y. Ho, E.K. Li, C.W. Lam//Lupus. - 2000. - №9. - THE RIVER 589-593.

58. Endocrinopathies in transfusion-associated iron overload / M.K. Kim, J.W. Lee,

K.H. Baek et al.//Clin Endocrinol (Oxf). - 2013. - ³78 (2). - THE RIVER 271-277.

59. Enhancing effect of IL-17 on IL-1-induced IL-6 and leukaemia inhibitory factor production by rheumatoid arthritis synoviocytes and its regulation by Th2 cytokines / M. Chabaud, F. Fossiez, J.L. Taupin, P. Miossec//J Immunol. - 1998. - №161. - THE RIVER 409-414.

60. Enns, C.A. Neogenin interacts with matriptase-2 to facilitate hemojuvelin cleavage / C.A. Enns, R. Ahmed, A.S. Zhang//J Biol Chem. - 2012. - ³287 (42). - THE RIVER 35104-35117.

61. Expression of angiogenic factors in juvenile rheumatoid arthritis: correlation with revascularization of human synovium engrafted into SCID mice / M.P. Scola, T. Imagawa, G.P. Boivin et al.//Arthritis Rheum. - 2001. - №44. - THE RIVER 794-801.

62. Expression of myeloid-related proteins 8 and 14 in systemic-onset juvenile rheumatoid arthritis / M. Frosch, T. Vogl, S. Seeliger et al.//Arthritis Rheum. - 2003. - №48. - THE RIVER 2622-2626.

63. Factors influencing quality of life (QOL) for Korean patients with rheumatoid arthritis (RA) / S.K. Cho, D. Kim, J.B. Jun et al.//Rheumatol Int. - 2013. - ³33 (1). - THE RIVER 93-102.

64. Firestein, G.S. Quantitative analysis of cytokine gene expression in rheumatoid arthritis / G.S. Firestein, J.M. Alvaro-Gracia, R. Maki//J Immunol. - 1990. - №144. - THE RIVER 3347-3353.

65. Foell, D. Proinflammatory S100 proteins in arthritis and autoimmune disease / D. Foell, J. Roth//Arthritis Rheum. - 2004. - №50. - THE RIVER 3762-3771.

66. Forre, O. Genetic epidemiology of juvenile idiopathic arthritis / O. Forre, A. Smerdel//Scand J Rheumatol. 2002 №31. THE RIVER 123-128.

67. FOXP3 + regulatory T cells in the human immune system / S. Sakaguchi, M. Miyara, C.M. Costantino, D.A. Hafler//Nat Rev Immunol. - 2010. - ³10 (7). - THE RIVER 490-500.

68. Friend of GATA and GATA-6 modulate the transcriptional up-regulation of hepcidin in hepatocytes during inflammation / E.T. Bagu, A. Layoun, A. Calve, M.M. Santos//Biometals. - 2013. - ³26 (6). - THE RIVER 1051-1065.

69. Frost, A.E. Anemia and erythropoietin levels in recipients of solid organ transplants / A.E. Frost, C.A. Keller//Transplantation. - 1993. - №56. - THE RIVER 1008-1011.

70. Fung, E. Manipulation of the hepcidin pathway for therapeutic purposes / E. Fung, E. Nemeth//Haematologica. - 2013. - ³98 (11). - THE RIVER 1667-1676.

71. Ganz, T. Hepcidin - a regulator of intestinal iron absorption and iron recycling by macrophages / T. Ganz//Best Pract Res Clin Haematol. - 2005. - ³18 (2). - THE RIVER 171-182.

72. Ganz, T. The hepcidin-ferroportin system as a therapeutic target in anemias and iron overload disorders / T. Ganz, E. Nemeth//Hematology Am Soc Hematol Educ Program. - 2011. - №2011. - THE RIVER 538-542.

73. Ganz, T. Hepcidin and iron homeostasis / T. Ganz, E. Nemeth//Biochim Biophys Acta. - 2012. - ³1823 (9). - THE RIVER 1434-43.

74. Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci / E.A. Stahl, S. Raychaudhuri, E.F. Remmers et al.//Nat Genet. - 2010. - №42. - THE RIVER 508-514.

75. Genome-wide association study of genetic predictors of anti-tumour necrosis factor (TNF) treatment in rheumatoid arthritis (RA) identifies associations with polymorphisms at seven loci / D. Plant, J. Bowes, C. Potter et al.//Arthritis Rheum. - 2010. - №63. - THE RIVER 645-653.

76. Gizinski, A.M. T cell subsets and their role in the pathogenesis of rheumatic disease / A.M. Gizinski, D.A. Fox//Curr Opin Rheumatol. - 2014. - ³26 (2). - THE RIVER 204-210.

77. Global prevalence of ankylosing spondylitis / L.E. Dean, G.T. Jones, A.G. Macdonald et al.//Rheumatology (Oxford). - 2013. - Dec 9. - 10 p.

78. Goodnough, L.T. Anemia, transfusion, and mortality / L.T. Goodnough, R.G. Bach//N Engl J Med. - 2001. - №345. - THE RIVER 1272-1274.

79. Goodnough, L.T. Erythropoietin, iron, and erythropoiesis / L.T. Goodnough, B. Skikne, C. Brugnara//Blood. - 2000. - №96. - THE RIVER 823-833.

80. Goswami, T. Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron
sensing / T. Goswami, N.C. Andrews//J Biol Chem. - 2006. - №281. - THE RIVER 28494-28498.

81. Grom, A.A. Macrophage activation syndrome: advances towards understanding pathogenesis / A.A. Grom, E.D. Mellins//Curr Opin Rheumatol. - 2010. - ³22 (5). - THE RIVER 561-566.

82. Guidi, G.C. Advancements in anemias related to chronic conditions / G.C. Guidi, C. Lechi Santonastaso//Clin Chem Lab Med. - 2010. - ³48 (9). - THE RIVER 1217­1226.

83. Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity. Vitamin and Mineral Nutrition Information System//World Health Organization, Geneva. - 2011. - URL: http://www.who.int/vmnis/indicators/haemoglobin.pdf

84. Hagve, T.A. Iron deficiency anaemia - interpretation of biochemical and haematological findings / T.A. Hagve, K. Lilleholt, M. Svendsen//Tidsskr Nor Laegeforen. - 2013. - ³133 (2). - THE RIVER 161-164.

85. Hahn, Y.S. Pathogenesis and clinical manifestations of juvenile rheumatoid arthritis / Y.S. Hahn, J.G. Kim//Korean J Pediatr. - 2010. - ³53 (11). - THE RIVER 921­930.

86. Hashimoto, M. Role of Th17 cells and innate immunnity for the induction of autoimmune arthritis / M. Hashimoto, T. Mimori//Nihon Rinsho Meneki Gakkai Kaishi. - 2012. - ³35 (6). - THE RIVER 463-469.

87. Heinrich, P.C. Interleukin-6 and the acute phase response / P.C. Heinrich, J.V. Castell, T. Andus//Biochem J. - 1990. - №265. - THE RIVER 621-636.

88. Henry, D. Prediction of response to recombinant human erythropoietin (R - HuEPO/epoetin-alpha) therapy in cancer patients / D. Henry, R. Abels, K. Larholt//Blood. - 1995. - №85. - THE RIVER 1676-1678.

89. Hepatic acute phase proteins - regulation by IL-6 and IL-1-type cytokines involving STAT3 and its crosstalk with NF-KB-dependent signalling / J.G. Bode, U. Albrecht, D. Haussinger et al.//Eur J Cell Biol. - 2012. - ³91 (6-7). - THE RIVER 496-505.

90. Hepatic iron overload induces hepatocellular carcinoma in transgenic mice expressing the hepatitis C virus polyprotein / T. Furutani, K. Hino, M. Okuda et al.//Gastroenterology. - 2006. - ³130 (7). - THE RIVER 2087-2098.

91. Hepcidin and HFE protein: Iron metabolism as a target for the anaemia of chronic kidney disease / E. Canavesi, C. Alfieri, S. Pelusi, L. Valenti//World J Nephrol. - 2012. - ³1 (6). - THE RIVER 166-176.

92. Hepcidin induction by pathogens and pathogen-derived molecules is strongly dependent on interleukin-6 / R. Rodriguez, C.L. Jung V. Gabayan et al.//Infect Immun. - 2014. - ³82 (2). - THE RIVER 745-752.

93. Hepcidin production in response to iron is controlled by monocyte-derived humoral factors / Y. Sasaki, Y. Shimonaka, K. Ikuta et al.//Int J Hematol. - 2014. - ³99 (1). - THE RIVER 12-20.

94. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization / E. Nemeth, M.S. Tuttle, J. Powelson et al.//Science. - 2004. - №306. - THE RIVER 2090-2093.

95. Hepcidin regulation by innate immune and infectious stimuli / A.E. Armitage,

L. A. Eddowes, U. Gileadi et al.//Blood. - 2011. - ³118 (15). - THE RIVER 4129-4139.

96. Hepcidin, a putative mediator of anaemia of inflammation, is a type II acute-phase protein / E. Nemeth, E.V. Valore, M. Territo et al.//Blood. - 2003. - №101. - THE RIVER 2461-2463.

97. Hepcidin, an urinary antimicrobial peptide synthesised in the liver / C.H. Park, E.V. Valore, A.J. Waring, T. Ganz//J Biol Chem. - 2001. - ³276 (11). - THE RIVER 7806-7810.

98. Hepcidin, the hormone of iron metabolism, is bound specifically to ALPHA-2 macroglobulin in blood / G. Peslova, J. Petrak, K. Kuzelova et al.//Blood. - 2009. - №113. - THE RIVER 6225-6236.

99. High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin / T. Tanno, N.V. Bhanu, P.A. Oneal et al.//Nat Med. - 2007. - №13. - THE RIVER 1096-1101.

100. Highly elevated serum levels of interleukin-18 in systemic juvenile idiopathic arthritis but not in other juvenile idiopathic arthritis subtypes or in Kawasaki disease / N. Maeno, S. Takei, Y. Nomura et al.//Arthritis Rheum. - 2002. - №46. - THE RIVER 2539-2541.

101. Hori, S. Control of regulatory T cell development by the transcription factor Foxp3 / S. Hori, T. Nomura, S. Sakaguchi//Science. - 2003. - №299. - THE RIVER 1057­1061.

102. Human plasmacytoid dendritic cells activated by CpG oligodeoxynucleotides induce the generation of CD4+CD25 + regulatory T cells / E.A. Moseman X. Liang, A.J. Dawson et al.//Journal of Immunology. - 2004. - Vol.173, №7. - THE RIVER 4433-4442.

103. IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis / S. Kotake, N. Udagawa, N. Takahashi et al.//J Clin Invest. - 1999. - №103. - THE RIVER 1345-1352.

104. IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis / Y. Komiyama, S. Nakae, T. Matsuki et al.//J. Immunol. -

2006. - №177. - THE RIVER 566-573.

105. IL-17 stimulates the production and expression of proinflammatory cytokines, IL - 1в and TNF-a, by human macrophages / D.V. Jovanovic, J.A. Di Battista, J. Martel-Pelletier et al.//J Immunol. - 1998. - №160. - the River 3513-3521.

106. IL-6 - STAT-3 - hepcidin: linking inflammation to the iron metabolism I. Stoian, B. Manolescu V. Atanasiu et al.//Rom J Intern Med. - 2007. - ³45 (3). - THE RIVER 305-309.

107. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin / E. Nemeth, S. Rivera V. Gabayan et al.//J Clin Invest. - 2004. - №113. - THE RIVER 1271-1276.

108. Il-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-TNF biologics: results from a 24-week multicentre randomised placebo controlled trial / P. Emery, E. Keystone, H.P. Tony et al.//Ann Rheum Dis. - 2008. - №67. - THE RIVER 1516-1523.

109. Immunoassay for human serum hepcidin / T. Ganz, G. Olbina, D. Girelli et al.//Blood. - 2008. - №112. - THE RIVER 4292-4297.

110. Immunologic tolerance maintained by CD25 + CD4 + regulatory T cells: their common role in controlling autoimmunity, tumour immunity, and transplantation tolerance / S. Sakaguchi, N. Sakaguchi, J. Shimizu et al.//Immunol Rev. - 2001. - №182. - THE RIVER 18-32.

111. Impaired skeletal development in interleukin-6-transgenic mice. A model for the impact of chronic inflammation on the growing skeletal system / F. De Benedetti, N. Rucci, A. Del Fattore et al.//Arthritis Rheum. - 2006. - №54. - THE RIVER 3551­3563.

112. Inappropriate expression of hepcidin is associated with iron refractory anaemia: implications for the anaemia of chronic disease / D.A. Weinstein, C.N. Roy, M.D. Fleming et al.//Blood. - 2002. - №100. - THE RIVER 3776-3781.

113. Increased expression of interleukin 17 in inflammatory bowel disease / S. Fujino, A. Andoh, S. Bamba et al.//Gut. - 2003. - №52. - THE RIVER 65-70.

114. Induction of hypoferremia and modulation of macrophage iron metabolism by tumour necrosis factor X. Alvarez-Hernandez, J. Liceaga, I.C. McKay, J.H. Brock / Lab Invest. - 1989. - №61. - THE RIVER 319-322.

115. Inflammation Regulates TMPRSS6 Expression via STAT5 / D. Meynard, C.C. Sun, Q. Wu et al.//PLoS One. - 2013. - ³8 (12) - e82127. - 10р.

116. Inflammatory regulation of iron metabolism during thioacetamide-induced acute liver injury in rats / T. Izawa, H. Murakami, K.K. Wijesundera et al.//Exp Toxicol Pathol. - 2014. - ³66 (2-3). - THE RIVER 155-162.

117. Influence of a recombinant human soluble tumour necrosis factor receptor Fc fusion protein on type II collagen-induced arthritis in mice / P.H. Wooley, J. Dutcher, M.B. Widmer, S. Gillis//J Immunol. - 1993. - №151. - THE RIVER 6602-6607.

118. Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression / J. Gao, J. Chen, M. Kramer et al.//Cell Metab. - 2009. - №9. P. 217-227.

119. Interferon gamma downregulates stem cell factor and erythropoietin receptors but not insulin-like growth factor-I receptors in human erythroid colony-forming cells / S. Taniguchi, C.H. Dai, J.O. Price, S.B. Krantz//Blood. - 1997. - №90. - THE RIVER 2244-2252.

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