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the Estimation of a role of microbiological changes at a syndrome of an angry intestine. A syndrome of superfluous bacteriemic growth

The structure of a microflora of the person depends on features of immune reactions, a food, a way of life, the transferred infections and agents of their treatment, and also an available chronic pathology [57, 76, 146].

It is proved, that the microflora of excrements of patients SRK essentially differs from a microflora of healthy faces [18, 67, 92, 134, 218]. Importance disbioticheskih changes at SRK consists in ability of an intestinal microflora to develop nejrotransmittery, influencing on ENS, that, in turn, changes secretion, a motility of an intestine and a threshold of visceral sensitivity [30]. The Finnish authors a method quantitative polimeraznoj chain reaction (PTSR) tap significant differences in the maintenance of some sorts of bacteria, such as Coprococcus, Collinsella and Coprobacillus [218]. Results of the quantitative analysis of a microflora of a colon at SRK testify to essential depression of obligate flora (bifidobaktery, laktobaktery, enterococci). Representatives of an is conditional-pathogenic microflora (staphilococcuses, hemolitic strains of an intestinal rod, protej, mushrooms of sort Candida) are sowed often from
Excrements of patients SRK, but their difference with indicators of healthy faces doubtfully [16, 131].

In modern researches special value is given to studying of communication of a syndrome of superfluous bacteriemic growth (SIBR) with development of chronic diseases of an intestine [4, 18, 212]. According to different sources, SIBR has been found out in 30-85 % of patients SRK [4, 211, 152, 171, 175, 190, 195, 209]. SIBR - a pathological condition at which in a lumen of proximal department of a small bowel it is found out more, than 105 WHICH/ML. As a rule, SIBR it is characterised by superfluous growth of mainly fecal microflora, including 141 strain of aerobes (such, as Streptococci (60-71 %), Escherichia coli (36­69 %), Staphylococci (13-25 %), Micrococci (22 %), Klebsiella (11-20 %)) and 117 strains anaerobov (such, as Bacteroides39 %, Lactobacillus25 %, Clostridium 20 %) [52, 54, 90, 107, 208, 211]. SIBR initiates inflammatory changes in a mucosa of a small bowel which, in turn, strengthen clinical implications of intestinal dysfunctions. In some cases SIBR is the reason of development of a microscopical inflammation of a small bowel: uploshchenie villuses, pathological changes of cryptás, augmentation intraepitelialnyh lymphocytes (IEL) [52, 151, 211]. It is important to notice, that in the presence of SIBR in a small bowel lumen disturbance of level secretory IgA becomes perceptible, that can have reflexion in disturbance of mechanisms of the control of number of bacteria [17, 52]. Many authors note presence SIBR and its participation in a pathogenesis at SRK [18, 26, 92, 143, 172, 207, 211], but there is also an opposite opinion that SIBR does not play any essential role in pathogenesis SRK [210].

As a result of the changed intestinal microflora, substances (free cholic acids, gidroksidy fat acids, bacteriemic toxins, proteases) and various metabolites (Phenolums, biogenic amines, etc.), influencing a motility of an intestine and a condition of its receptor apparatus [16, 29, 31, 60, 93, 140, 185, 208, 211] are developed. Special value have korotkotsepochechnye monokarbonovye acids and their salts which concentration at patients SRK is lowered. At SRK the bacteriemic proteolysis, that changes
Influences on slizeobrazovanie. As a result of disturbance of power supply of a mucosa of an intestine the hypoxia develops, the trophicity is broken, the dysbacteriosis is aggravated, function of goblet cells and structure glikoproteinov changes, that, in turn, reduces protective functions of a mucosa and influences a threshold of painful sensitivity. The vicious vicious circle promoting maintenance of arisen changes of a motility and sensitivity of the receptor apparatus of an intestine [11, 29] is as a result framed.

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Scientific source TIPIKINA Maria Jurevna. ESTIMATION of the ROLE of INFLAMMATORY And MICROBIOLOGICAL CHANGES AT the SYNDROME of the ANGRY INTESTINE At CHILDREN. The dissertation on competition of a scientific degree of the candidate of medical sciences. St.-Petersburg - 2014. 2014

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