THE CONCLUSION

The bronchial asthma is multifactorial disease and, in the light of achievements of modern medicine and molecular biology, formiyoruetsja at complex influence of internal and external risk factors.

The research objective of our work consisted in an establishment klinikoyoepidemiologicheskih, genetic both ethnic features BA and influence of a tobacco smoking on its current at teenagers of Transbaikalia for working out diffeyorentsirovannyh approaches to preventive maintenance and treatment.

Following problems were put:

To define prevalence of a bronchial asthma and its symptoms among teenagers of the Buryat and Russian ethnogroups living in a countryside of Transbaikalian edge.

To estimate prevalence of a tobacco smoking among the teenagers sick of a bronchial asthma, to compare it with frequency of respiratory symptoms and clinical features of disease.

To carry out the analysis of associations of polymorphic variants of genes-candidates of development of a bronchial asthma (FCER2, ADRB2, TNFA, GSTM1, NOS2, NOS3и GSDMB) and predispositions to a tobacco smoking (THOI, CHRNA5) with formiyorovaniem diseases at teenagers to identify markers povyshennoyogo risk and interethnic differences.

To establish value of intergene interactions of the investigated genes - of candidates at a bronchial asthma at teenagers Buryat and Russian etnoyogrupp.

To define communication investigated polimofnyh variants of genes - of candidates of formation of a bronchial asthma and predisposition to niyokotinovoj dependences with features of a current, age of a manifestation of disease, level of the general IgE in blood serum and a floor with the account etnicheyoskoj accessories.

To estimate the contribution sochetannogo influences genetic and vneshneyosredovyh (an exposition to a tobacco smoke) factors on development of a bronchial asthma.

Scientifically to prove directions complex lechebnoyoreabilitatsionnyh the actions including educational programs, therapy by modern Mucolyticums and vegetative inhibitors lejkotrienov.

In the spent work following methods of research were applied:

1. Epidemiological methods of research of prevalence astmo - similar symptoms (APS) and BA among rural teenagers of Transbaikalia, rasprostrannennosti an active and passive tobacco smoking, the analysis of the status of smoking at patients BA.

2. Clinico-Allergologichesky, functional, laboratory obsledovayonie.

3. Molekuljarno-genetic methods of research (allocation genomnoj DNA, studying of polymorphism of genes by method PTSR with the subsequent PDRF the analysis with use prajmerov for genotipirovanija).

4. Statistical methods, including calculation of the relation of chances, otnosiyotelnogo risk, a confidential interval, the relation of relative risks, attributive risk, population attributive risk for definition of risk factors of formation of disease; rangovoj correlations on SpirmeYOnu for studying of interrelations between outwardly-sredovymi risk factors and disease symptoms.

EpiDemiologija a bronchial asthma at the teenagers living in a countryside of Transbaikalian edge: ethnic differences.

Results dynamic epidemiological isyosledovanija prevalence of symptoms BA (under program ISAAC) with uchyoyotom a national identity are analysed.

At aboriginals (Buryat) prevalence APS has appeared more low, than at Russian teenagers. In dynamics 2005-2006гг. And 2008-2009гг. At podrostyokov, living in a countryside to Transbaikalia, prevalence APS at the Buryat it was authentically enlarged from 15,6 % to 19,3 % (p