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the comparative analysis of immunologic indicators on groups

At a following stage the comparative analysis of quantitative characteristics of studied immunologic indicators on groups is carried out.

Quantitative characteristics of immunologic indicators in the comparative analysis have shown, that maintenance CD4 + - lymphocytes was minimum in group with LFT, at "bend" tuberkulinovyh assays a little above, and in control group above, than in group with LFT and "bend" tuberkulinovyh assays, quantity CD16 + - lymphocytes raised in comparison with the control (8,9 %) on 5 % at children with "bend" tuberkulinovyh assays and on 7 % in comparison with LFT. Level IgE as much as possible high at local forms of a tuberculosis, at "bend" tuberkulinovyh assays IgE was more low in comparison with LFT and practically did not differ from that healthy children, having slightly big indicators.

Fig. 2. Visualisation of average value of immunologic indicators in studied groups.

Level of production IFN-y in the test to system with FGA and DST certain patterns also have. IFN-y in the test to system with FGA the maximum value has in control group, in groups of children with a tubercular infection has practically identical value and in comparison with the control is lowered, on the average, on 400 pg/ml, (in 1,8 times it is less).

Fig. 3. Distribution of indicators of level of production IFN-y in the test - system in vitro with FGA at children of studied groups (on a vertical - pg/ml; across - studied groups).

Level of production IFN-y in the test to system with DST has a zero indicator in group of healthy children, and raises at children with a tubercular infection.

Fig. 4 Distribution of indicators of level of production IFN-y in the test - system in vitro with DST studied groups (on a vertical - pg/ml; across - studied groups).

The carried out analysis of level IFN-y with DST in groups, has shown, that its value depends on result of a Mantoux reaction 2ТЕ, the more expressed result (the size of a papule), the more than its value.

Thus, raised emission IFN-y in the test - system in vitro with DST, on the average, on group is registered as at children with "bend" tuberkulinovyh assays (41,2 pg/ml) and at children with LFT (38,8 pg/ml) and is not observed in group of healthy children (a Fig. 4).

Summarising results of the given investigation phase it is possible to conclude, that at children infected MBT, both with diagnosis LFT, and with "bend" tuberkulinovyh assays concerning group of healthy children similar changes as quantitative immunologic indicators are observed:
Depression of level CD4 + - lymphocytes, rising of level CD16 + - lymphocytes, rising of level IgE, and indicators of functional activity of cells of system of immunity (depression stimulirovannoj production IFN-y in the test - system in vitro with FGA and rising that in the test - system with DST). However, it is possible to notice, that depth of change of such immunologic indicators, as the maintenance (percentage and absolute) CD4 + - CD16 + - lymphocytes, Ig E in group of children with LFT are expressed in larger degree, than in group of children with "bend" tuberkulinovyh assays. Whereas stimulirovannaja production IFN-y in the test - system in vitro with FGA and level of emission IFN-y (DST) at children of the given groups practically coincides.

3.6.4.

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Scientific source Ahmerova Tatyana Efimovna. IMMUNODIAGNOSIS OF DIFFERENT MANIFESTATIONS OF TUBERCULOSIS INFECTION IN CHILDREN. Thesis for the degree of candidate of medical sciences. SAMARA - 2014. 2014

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Other medical related information the comparative analysis of immunologic indicators on groups:

  1. THE TABLE OF CONTENTS
  2. the comparative analysis of immunologic indicators on groups
  3. THE LIST OF THE USED REFERENCES
  4. THE LITERATURE LIST
  5. THE LITERATURE LIST
  6. THE CONCLUSION
  7. Chapter 1 the literature Review
  8. immunologic efficiency and safety of bacterination BTSZH of children born from sick HIV-infections of women
  9. THE LITERATURE LIST
  10. Abatatsept
  11. THE LITERATURE LIST
  12. Chapter 2. The GENERAL CLINICAL CHARACTERISTIC of PATIENTS And RESEARCH METHODS
  13. Traditional methods of inspection
  14. Chapter 7 DISCUSSION of RESULTS of RESEARCH
  15. INTRODUCTION