the Characteristic of the preparations used for treatment
As basic therapy patients with GER and ZFP received prokinetik trimebutin. Trimebutin (2 (dimetilamino)-2-fenilbutilefir 3,4,5-trimetoksibenzojnoj acids) have been synthesised for the first time Laboratoires Jouveinal (France) in 1969 Trimebutin (Trimedatj) is an agonist peripheric opiatnyh receptors of three basic types (ts, 5,), located on gladkomyshechnyh cells on all extent zheludochnoyokishechnogo a tract.
Result of it is the modulating effect trimebutina on an alimentary system motility. Besides, it influences visceral sensitivity of organs of digestion, having moderate analgetic an effect, including. And at SRK. At the heart of this effect preparation influence on antinotsitseptivnuju system of an organism with rising of a threshold of painful sensitivity, updating of an estimation of a pain, depression of sensitivity of receptors to inflammation mediators lays. Trimebutin influences and humoral regulation of a motility of a gastroenteric tract, raising secretion motilina and reducing level of Gastrinum, a glucagon, a pancreatic polypeptide, insulin and a vasoactive intestinal peptide.Other pharmacological effects trimebutina are pressure decrease of the bottom esophageal sphincter, acceleration oporozhnenija a stomach. Thanks to action on various types opiatnyh receptors trimebutin restores normal physiological activity of a musculation of an intestine, reducing it in case of rising and, on the contrary, in this connection it can be applied at all forms SRK. At SRK with a diarrhoeia trimebutin eliminates the raised motility of an intestine, accelerates transit on an intestine in case of a constipation, reduces visceral hypersensitivity, renders spasmolytic effect.
Trimebutin is issued in the form of tablets on 200 mg with one riskoj and 100 mg with two risks. To children is elderly to 6 mes a preparation it is prescribed on 12,5 mg
2-3 times a day, at the age from 6 mes till one year — on 25 mg 2 times a day, at the age of 1-5 years — on 25 mg 3 times a day, aged are more senior 5 years — on 50 mg 3 times a day, to children aged is more senior 14 years and the adult — on 100-200 mg 3 times a day. [20,71,91,92].
2.7 Methods of statistical processing of the received results
Statistical processing of the received results is spent on the individual computer by means of spreadsheets «Microsoft Excel», a package of applied programs «Statistica for Windows» 7.0, StatSoft іпс. (USA).vse received quantitative anamnestic, clinical, datas of laboratory are processed by a method of variation statistics. For each quantitative parametre have been defined: average value (), srednekvadraticheskoe a deviation (), an average error (m), 95 %
Confidential interval, for qualitative data - frequency (%). For comparison of numerical data (after check of quantitative data on normal distribution) used a method of variance analysis ANOVA (for 3 groups), and also applied t-criterion Stjudenta for 2 independent vyborok. Comparison of parametrical data was spent with use of criterion the Mine-uitni (for 2 groups) for untied sets. For a finding of differences between quality indicators used a method h 2 with amendment Jetsa on a continuity, and also Fisher's exact criterion for small vyborok.
Statistically significant differences were considered at p
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