a role of a dysplasia of a connecting tissue at a pathology of organs of urinary system

The pathology of organs of urinary system (OMS) concerns now one of the major problems of a medical science and practice, and in structure of a case rate of children of the Russian Federation occupies one of leading places.

The concept «Chronic illness of kidneys» (HBP) reflects uniform approaches to treatment improvement of quality, improvement of outcomes at patients with diseases OMS and is used in children's nephrology since 2003 [49, 74, 75, 76, 77, 79, 102, 143, 270]. Under HBP it is accepted to understand presence of any markers of damage of kidneys, persistent within more than three months without dependence from the nosological diagnosis [143]. Term has been chosen 3 months because in the given terms acute variants of development of dysfunction of kidneys come to the end with recover or lead to obvious clinico-morphological signs of synchronisation of process [143, 261]. HBP is nadnozologicheskim concept, the reasons of its allocation are based on unity of the basic pathogenetic mechanisms of advance of pathological process in kidneys, a generality of many risk factors of development and disease advance at damages OMS of a different aetiology [143].

Diagnosis HBP should be established on the basis of following criteria [143]:

1. Presence of any clinical markers of damage of kidneys,

Confirmed with an interval not less than 3 months;

2. Any markers of irreversible structural changes of the organ, taped unitary at intravital morphological research of an organ or at its visualisation;

3. Depression of rate of a glomerular filtration (SKF)