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research of level of concentration of antimicrobial peptides of a mouth at diseases parodonta

At the analysis of a hygienic condition of an oral cavity on index OHI-S (the simplified index of hygiene of an oral cavity (GAMES s) on Gren J.C., Vermillion J.K.) it has been taped, that 44 children had satisfactory level of hygiene of an oral cavity (value of an index 1,3-3,0), from them 34 children suffering AtD of moderate severity level; 10 children from comparison group.

Good hygiene of an oral cavity became perceptible at 16 children, from them 4 children with atopicheskim a dermatitis of various severity level, 12 children - comparison groups. Bad level of hygiene at surveyed children has not been taped.


At research of index RMA 21 child suffered a moderate severity level ulitis, from them 18 children suffering AtD of various severity level; 3 children from comparison group. Easy degree of an ulitis was found out in 23 children, from them 15 children with AtD and 8 children without an atopy. Children with an ulitis of serious degree in our research were absent.

At all children (44 children) the catarral form of an ulitis easy and moderate severity level is taped.

The average level katelitsidina in a saliva in the presence of an ulitis at children with atopicheskim a dermatitis has made 0,7 +/-0,3 ng/ml; average value a-defenzinov a mouth - 7,1 +/-3,7 ng/ml.

Concentration LL-37 in a stomatic liquid at children with AtD at moderately severe an ulitis and at children with atopicheskim a dermatitis at easy degree of an ulitis statistically had no authentic differences (n=18, Me 0,6 ng/ml; n=15, Me 0,8 ng/ml; accordingly, r =0,43).

At level comparison katelitsidina a saliva of children of group of comparison and at children with AtD, suffering an ulitis of various severity level essential difference (n=11, Me 1,1 ng/ml, 50 % interkvartilnyj scope 0,3.1,2 ng/ml became perceptible; n=33, Me 0,6 ng/ml, 50 % interkvartilnyj scope 0,14.0,8 ng/ml, accordingly), р=0,037.

At concentration comparison katelitsidina a saliva at children with atopicheskim a dermatitis at presence and absence of an ulitis the following pattern is taped: concentration LL-37 of a saliva at children with an ulitis was more low, than at children without that (n=33, Me 0,6 ng/ml, 50 % interkvartilnyj scope 0,14.0,8 ng/ml; n=5, Me 0,9 ng/ml, 50 % interkvartilnyj scope 0, 4... 1,1 ng/ml, accordingly), р=0,012.

At level research a-defenzinov the stomatic liquid at various severity level of an ulitis at children with atopicheskim a dermatitis accepts following results: concentration a-defenzinov in a saliva at moderate severity level of an ulitis and at children with easy severity level of an ulitis not
Had statistically authentic differences (n=18, Me 7,4 ng/ml, 50 % interkvartilnyj scope 4,3. 10,0 ng/ml; n=15, Me 7,2 ng/ml, 50 % interkvartilnyj scope 3,0.10,0 ng/ml, accordingly, r =0,43).

At concentration comparison a-defenzinov in a saliva at children with atopicheskim a dermatitis at children at presence and absence of an ulitis following results (n=33, Me 7,1 ng/ml, 50 % interkvartilnyj scope of 3,3.10,0 mkg/ml are received; n=5, Me 6,9 ng/ml, 50 % interkvartilnyj scope 5,4... 8,9 ng/ml, accordingly, r =0,23). Statistical reliability it is not taped.

Also we had been spent comparison of level of concentration LL-37 at children of group of comparison depending on presence or absence of an ulitis: (n=11, Me 1,2 ng/ml, 50 % interkvartilnyj scope 0,3.1,35 ng/ml; n=11, Me 0,9 ng/ml, 50 % interkvartilnyj scope 0,4. 1,62 ng/ml, accordingly). Statistical reliability it is not taped, р=0,204.

Thus, it is taped, that level katelitsidina at children with atopicheskim a dermatitis is lowered in the presence of inflammatory diseases parodonta (in our case, an ulitis) whereas concentration a-defenzinov essentially does not change.

In group of comparison there are no essential changes in level of antimicrobial peptides of an oral cavity (a-defenzinov, katelitsidina) depending on presence or absence of an ulitis.

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Scientific source Kulakova Elena Vladimirovna. Value of antimicrobial peptides in formation of a pathology of an oral cavity at children with atopicheskim a dermatitis. The dissertation on competition of a scientific degree of the candidate of medical sciences. Moscow - 2014. 2014

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Other medical related information research of level of concentration of antimicrobial peptides of a mouth at diseases parodonta:

  1. INTRODUCTION
  2. antimicrobial peptides of an oral cavity
  3. research of level of concentration of antimicrobial peptides of a mouth at diseases parodonta
  4. Chapter 4 the Conclusion