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The table № 5.3 Place infliksimaba, etanertsepta and abatatsepta in algorithm GIB JUIA

(By results of own research)

Articulate a variant

JUIA

System variant

JUIA without extraarticular implications (c an active arthritis)

System variant JUIA with extraarticular implications
1 I линия:и-ФНО

(infliksimab, etanertsept) or abatatsept

2 I линия:и-ФНО or

abatatsept

1 I line Totsilizumab

2 I linijai-FnO (infliksimab, etanertsept) or abatatsept

1 I a line

Totsilizumab

Anakinra

2 I a line

Totsilizumab

Anakinra

3 I a line

I-TNF (infliksimab, etanertsept) or abatatsept

1. At articulate variant JUIA studied preparations (infliksimab, etanertsept, abatatsept) have shown comparable efficiency, and can be recommended as preparations of a choice of the first line, or the second line, at an inefficiency of the first preparation.

2. As, at system variant JUIA efficiency of studied preparations (infliksimaba, etanertsepta, abatatsepta) made at children without extraarticular implications about 60 % and at children with extraarticular implications less than 50 %, it is possible to recommend them as preparations of the second line, at an inefficiency or intolerance of preparations of the first line, to children with system variant JUIA without extraarticular implications; as preparations of the third line, at an inefficiency and intolerance of preparations of the first and second lines, at children with system variant JUIA with extraarticular implications.

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Scientific source Loskutova Olga Jurevna. Efficiency and safety of genno-engineering biological preparations (infliksimab, etanertsept, abatatsept) at children with various variants juvenilnogo an idiopathic arthritis. The DISSERTATION on competition of a scientific degree of the candidate of medical sciences. Moscow - 2014. 2014

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