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possible ways of influence of viruses of herpes on a thermoregulation

Various laboratories carried out researches tsitokinovogo a spectrum at patients with chronic gerpesvirusnoj an infection [78, 79, 86, 89]. Cytokines are the substances synthesised by immunocompetent cells by means of which intercellular interaction within the limits of immune system is carried out.

It is shown, that cytokines also can be synthesised in TSNS by glial and nervous cells. Some proinflammatory cytokines operate as endogenous pyrogens, others — as
Antipyretic substances. Proinflammatory cytokines with pyrogenic effect are most known and studied is ИЛ-1, ИЛ-6, the TNF, and cytokines-antipyretics are ИЛ-1ра, ИЛ-10 [110].

Results of the spent researches differ appreciable variability [7, 34, 42, 75, 121, 140]. One researchers notice, that exists three types of reaction in reply to presence at an organism gerpesvirusov. At the first type concentration in blood IFN, ИФН-y, ИЛ-10, ИЛ-6 and FNOa is raised, that, according to authors, is an indicator of primary reaction of an organism on antigen introduction. The second type of reaction is characterised by dropping of concentration ИФН-y, ИЛ-6 and ИЛ-8, that leads to suppression of intracellular antiviral mechanisms. At the third type of reaction rising of level IFN, IFN - y, Silt - 1в, ИЛ-6 and FNOa is observed, that is identical to the first type, but, under the statement of authors of research, testifies to synthetic activity of the infected leucocytes in which it is carried out persistentsija a virus [78, 103, 106, 108].

In earlier researches the same authors have shown intensifying of production If-a/v, ИЛ-10, FNO, ИЛ-6 at chronic gerpesvirusnoj to an infection [79].

Other authors, on the contrary, underline, that level ИЛ-1в at some patients with chronic gerpesvirusnoj an infection did not exceed standard value, also concentration ИЛ-6 in blood serum [65] also did not change. O.O.Obuhova [45] in the work has shown, that average level ИЛ-1в raises only at an exacerbation chronic gerpeticheskoj infections. Level ИЛ-1в in research of exacerbations chronic gerpeticheskoj infections was high and significantly differed from average indexes. At the same time this indicator very widely varied at different patients and fluctuated from 7 pg/ml to 2000 pg/ml, that is there were patients and with indicators below norm. Repeated excess of norm ИЛ-1в became perceptible at 68,52 % of patients [45]. The following
Data results R. A. Seder [195] and a number of other authors: by results of their research the transition moment gerpesvirusnoj infections in the persistent form is characterised by augmentation of synthesis of cytokines T-helperami 2 types: ИЛ-4, ИЛ-5, ИЛ-9, ИЛ-10, that leads to intensifying of the humoral answer and transformation of the acute form of disease in latent persistirovanie a virus [146, 195].

Production ИФ-Y is estimated by different authors or as lowered, or, on the contrary, raised [7, 39, 111].

Remains obscure how subfebrile level of temperature is formed, instead of occurs more expressed rise in temperature, probably, it is bound to rising and antipyrogenic cytokine ИЛ-10 which is available on a level with rising of pyrogenic cytokines, and also a duality of action the TNF which can act not only in a role of the pyrogenic factor, but also interfere with rise in temperature.

Thus, it is possible to conclude, that the most typical for persistirujushchihgerpesvirusnyh infections is rising of concentration ИЛ-6, If, in and FNO. Thus, comparing a spectrum of pyrogenic cytokines with cytokines which raise at chronic gerpesvirusnoj infections, it is possible to draw a conclusion, that the long subfebrile condition can be caused constantly raised cytokines in a peripheric blood flow. It has been shown, that all of them are capable to influence a hypothalamus by means of stimulation of synthesis ПГЕ-2 and, thus, to stimulate rise in temperature [147].

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Scientific source Lebedeva Tatyana Mihajlovna. Clinico-pathogenetic value gerpesvirusov at long subfebrile conditions at children. The dissertation on competition of a scientific degree of the candidate of medical sciences. Moscow - 2014. 2014

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