motility Correction
Allocate some groups spazmolitikov, depending on the basic mechanism of action for stages of reduction of a muscular fiber:
1. Anticholinergic (M-holinoblokatory): atropine, Methacinum, Platyphyllinum, pirenzepin, etc.
are not applied to course treatment of patients SRK, in connection with absence of selectivity, low efficiency, a considerable quantity of by-effects [54, 83].2. Blockers fosfodiesterazy: a papaverine, Drotaverinum. Also are not applied to course treatment of patients SRK, in connection with absence of selectivity, the big risk of development of a hypomotor dyskinesia and a hypotension sfinkternogo the apparatus GASTROINTESTINAL TRACT [54].
3. Regulators serotoninovyh receptors (agonists of 5-5-receptors, antagonists of 5-5-receptors). Linkage of a serotonin with 5-NT3 promotes a relaxation, and with 5-NT4 - to reduction of a muscular fiber, however these mechanisms up to the end are not studied. Now from preparations of this group are known the antagonist 5-NT3 - alosetron, a full agonist 5-NT4 - prukaloprid and a partial agonist 5-NT4 - tegaserod. At children preparations are not used, in view of serious by-effects [54, 78].
4. Regulators opiatnyh receptors (blockers ts - and about - receptors, activators of k-receptors): trimebutin. At linkage with ts - and 3-opiatnymi stimulation, and to k-receptors - retardation of a motility of an intestine occurs receptors miotsitov. Now the preference to the given group spazmolitikov, including at children, for course treatment of patients SRK [36, 54] is given.
5. Blockers № '-channels (mebeverin) and blockers Sa of ++-channels (pinaverija Bromidum). Efficiency pinaverija Bromidum and mebeverina at patients SRK is shown in researches of domestic authors [54, 55].
Studying of expediency of application of others spazmolitikov in therapy SRK proceeds. In research E. Forte from co-workers. (2012), efficiency otilonija Bromidum in elimination of symptoms SRK which is comparable to that pinaverija Bromidum and mebeverina [42] is established.
Last years new directions of therapy SRK at adults are developed. For example, in work W. D. Chey from co-workers. (2012) efficiency of application ljubiprostona - the selective activator of chloride channels which is applied at SRK with a constipation [42] is shown.
Among new preparations for treatment SRK allocate azimadolin (an agonist k-opioidnyh receptors). In research A. W. Mangel from co-workers. (2012) it is established, that azimadolin reduces expression of a painful syndrome, normalises frequency of a chair [42].
Krofelemer - the medicinal preparation received from pitch of tree Croton lechleri, growing in the South America, - has shown antisecretory influence on cells in vitro, that bind with ingibitsiej transmembrane carrying over of ions [70]. In 2008 scientists from the USA [174] have found out, that krofelemer at SRK with a diarrhoeia does not influence intestinal function, but stops a pain and discomfort.
Thus, despite wide enough range of possible pharmacological influences on the intestine motility, only some
Preparations are resolved in children's practice, but also their efficiency at SRK at children is studied insufficiently.
1.3.2
Скачать оригинал источника
Other medical related information motility Correction:
- 1. Modern representations about an aetiology and a pathogenesis of functional disturbances of a motility of organs of digestion
- the List of the used literature:
- INTRODUCTION
- modern methods of treatment of constipations at children
- treatment Methods
- THE LITERATURE LIST
- programs of regenerative correction perinatalnyh disturbances of nervous system at children
- infantile intestinal gripes
- correction of infantile intestinal gripes
- THE LITERATURE LIST
- structure of congenital defects at a syndrome of Down
- THE CONCLUSION
- THE TABLE OF CONTENTS
- motility Correction
- Chapter 6 the COMPARATIVE ESTIMATION of EFFICIENCY of THERAPY of the SYNDROME of the ANGRY INTESTINE At CHILDREN
- Chapter 7 DISCUSSION of RESULTS of RESEARCH
- THE LITERATURE LIST
- Infantile intestinal gripes
- Correction of infantile intestinal gripes
- THE LITERATURE LIST