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Markernyj a spectrum gerpesvirusnyh infections, at children with a long subfebrile condition.

On set clinico-datas of laboratory, at 112 children from 127 obsledovanyh (88,2 %) — have been taped markers GV. From 127 (11,8 %) — markers GV have not been found out In 15 children (fig.

5).

Drawing 5. Revealing of markers gerpeticheskih infections at children with DS (n=127)

On set clinico-datas of laboratory, to 15 children with DS without markers GVI, diagnoses have been put: the Panniculitis (1). A parainfluenza (2). A tonsillitis of a streptococcal aetiology (Streptococcuspneumonia) (1). Enterovirusnaja an infection (1). The FLU - And (2), a pneumocystosis against current ORVI (2), a respiratory clamidiosis (1). A chronic coloenteritis, an anaemia. Gastro-ezofagalnyj a reflux. A subthalamic syndrome.

Gormonalnosubkompensirovannyj gipotirioz (1). The Tserebroastenichesky syndrome (2). A dolichosigma, a lambliasis (1), tubinfitsirovannost (1). These data confirm literary data about polietiologichnosti a long subfebrile condition.

At 112 (88,2 %) - have been taped markers GVI testifying to various forms of an infection. Frequency of detection of markers mono and mikst

gerpeticheskih infections at children with a long subfebrile condition predstavlenana a drawing 6.

Drawing 6. Frequency of detection of markers mono-and admixed gerpeticheskih viruses at children with a long subfebrile condition (n=112)

Apparently on fig. 6, at DS at children admixed gerpesvirusnaja the infection meets in 3 times more often (83 patients from 112 (75 %), than a monoinfection — at 29 patients (25 %). In group with mono - markers GVI children with TSMVI — 13 of 29 sick (44,8 %), with the EBV-INFECTION — 12 of 29 sick (41,8 %) prevailed. Other viruses in the form of a monoinfection were taped much less often: ВГЧ-6 at 3 from 29 sick (10,3 %) and VPG I and II types at 1 from 29 sick (3,1 %).

On fig. 7представлены variants of combinations of markers gerpeticheskih infections at children with DS.


Drawing 7. Variants of combinations of markers gerpeticheskih viruses at patients with a long subfebrile condition, n=83

Apparently izris. 4, at % of children with a long subfebrile condition combination TSMV and EBV — 20 of 83 sick (24,1 %) has been taped. In any combinations met TSMV (44,35 %) and veb (53,41 %) is more often. Combination TSMV + VGCH 6 and VPG І, ІІ +ЦМВ+ЭБВ+ВГЧ6-on 12 patients from 83 (14 is equally often noted. 4 %); less often ЭБВ+ВГЧ6 at 8 patients from 83 (9,6 %); VPG І, ІІ +ЭБВ and ЦМВ+ЭБВ + ВГЧ6 on 7 patients from 83 (8,4 %); VPG I, II +ЦМВ and VPG I, ІІ +ЦМВ+ВГЧ6 по5 patients from 83 (6. 1 %); VPG І, ІІ +ЭБВ + ВГЧ6 at 4 sick из83 (4,8 %); VPG І, ІІ +ЦМВ+ЭБВ at 3 from 83 (3. 6 %).

Thus, markers EBV and TSMV in various combinations met at more, than half of children (73 children and 64 children accordingly, that has made 57,4 % and 50 %, accordingly). More than at 1/3 children infection VGCH 6 types in various combinations (48 children - of 37,8 %) has been taped. Most less often met VPG 1 type — in 28,3 % of cases (38 children).

The received results testify that markers TSMV and EBV approximately with identical frequency are defined in a case mono-and a multi-infection and prevail over markers VGCH - 6 and VPG.

Markers ВГЧ6 and VPG I in group mono infections were taped in 5 times less often, than in group of multi-infections when their participation was defined almost in half of cases.

Laboratory inspection of children with syndrome DS has taped high chastotulatentnyh forms GVI, in mono-and the admixed variants, on what low levels of antibodies to viruses of class IgG in blood specify.

Revealing klinicheskihform GVI at children with a long subfebrile condition is presented in table 6.

Table 6 Revealing of forms GVI at children with a long subfebrile condition. n=112

Clinical forms Abs. %
Active primary infection 15 13,3
Reaktivirovannaja 34 30,4
The latent 63 56,3
In total 112 100

Thus, use of a complex of modern methods of diagnostics has allowed to diagnose following clinical forms GVI for 112 children: at 15 (13,3 %) from 112-aktivnujupervichnuju GVI, at 34 (30,4 %) iz112-reaktivirovannuju, at 63 (56,3 %) from 112-latent.

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Scientific source Lebedeva Tatyana Mihajlovna. Clinico-pathogenetic value gerpesvirusov at long subfebrile conditions at children. The dissertation on competition of a scientific degree of the candidate of medical sciences. Moscow - 2014. 2014

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