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Correction of infantile intestinal gripes

At treatment of the child with MKK it is necessary to consider all factors of prospective "vicious circle" on purpose reduction of each of them. Correction FRZHKT should be begun with references on leaving and a food.

During attack MKK of the child it is recommended to take on arms, to swaddle, wear on arms (but not to shake), to speak with it. Visual, tactile and acoustical stimulus can have abirritating an effect. The human image and a voice are positively perceived by the child in the first months of a life. It is necessary for child to feel care and love of mother. It has been noticed, that crying decreased at more frequent feeding and during wearing on arms [118].

Frequent feeding by small portions promotes the best mastering of nutrition, having more uniform stimulating influence on level gastrointestinalnyh hormones, in particular, cholecystokinin (HTSK). Considering role BKM in development MKK in a part of children, mothers of children on thoracal feeding should observe bezmolochnuju a diet, and to children on artificial feeding - albuminous hydrolysates. Mother is recommended to keep a diary with the detailed description behaviour of the child. To not allergic genesis MKK testifies tsutstvie effect within 2-3 days after exception BKM.

the Raised level of hydrogen in exhaled air at children with MKK - an indirect sign transitional LN. Hence, the quantity of consumed lactose is necessary for reducing. For children, being on thoracal feeding use of a preparation of a lactase, with addition in preliminary decanted milk before each feeding is the most expedient. To children with LN, being on artificial feeding are shown nizkolaktoznye to an admixture.

efficiency Proofs at MKK have been received on application of cholinolytic of dicyclomine of a hydrochloride [172], however because of its by-effects it is not authorised primenenjat at children's age. Recommended for cupping

MKK phenobarbital had no expected effect. In favour of efficiency simetikona convincing data also it is not received [160].

Modern representations about influence of an intestinal microflora on a genesis of an inflammation and dismotoriki which underlie MKK, allow to open new prospects in therapy of the given syndrome. Recently a number of the researches which have shown efficiency probiotikov at treatment MKK is spent. According to definition the CART, probiotiki the live microorganisms improving health of an organism of the owner represent, at use in certain quantities. The list probiotikov annually extends and now totals tens the kinds concerning, basically, to a sort laktobatsill and bifidobaktery. But not all probiotiki have identical efficiency. Action mechanisms probiotikov can differ even at representatives of one sort. At children with MKK, the best effect is received at application Lactobacillus reuteri - laktobatsill, occupying GASTROINTESTINAL TRACT the person, allocated from female milk and corresponding to all safety requirements shown to probiotikam which well transfer acidic medium of a stomach and are steady against the majority of antibiotics. There is a number of the researches which have shown efficiency and safety L. reuteri at use at children of thoracal age with constipations [105], a diarrhoeia [80] and preventive maintenance of intestinal infections [175]. F. Savino from co-workers. [26] investigated 90 children who are on thoracal feeding, at the age from 21 till 90 days with symptoms MKK.

One group (45 children) received L. reuteri once a day, another (45 children) - simetikon on 60 mg a day, within 28 days. All mothers observed bezmolochnuju a diet and kept a diary. Inspection of children was spent in dynamics: in 1, 7, 14 and for 28 day. Upon termination of term of observation of duration of crying for 50 % also has more decreased at 95 % of children receiving L. reuteri, and only at 7 % of children receiving simetikon. Results had no dependence on presence of risk of development of an allergy. The given research has shown high efficiency L. reuteri in treatment of syndrome MKK in comparison with therapy simetikonom.

As well as others probiotiki, L. reuteri influences permeability of an intestinal epithelium, renders antiinflammatory effect and possesses immunomodulirujushchim action. Last has been proved in experiment on cultures of cells of an intestinal epithelium of the person, spent D. Ma from co-workers. [136]. It has been shown, that L. reuteri suppresses stimulirovannuju TNF - and # 945; secretion IL-8 as at the expense of inhibition of degradation of the inhibiting factor I and # 954; B and translocation preventions in a kernel of the nuclear factor of inflammation NF and # 954; B, and at the expense of direct suppression of expression RNK IL-8. It is important to notice, that the effect was rendered only by live bacteria; neither killed, nor lysates of bacteria did not possess similar action. The effect was proportional to dose L. reuteri.

Mechanisms of antiinflammatory action of various kinds probiotikov differ from each other. So, some of them stimulate synthesis of antiinflammatory cytokines (IL-10), L. johnsonii strengthens development TGF - and #946;. Bifidobakterii do not render stimulating influence on NF and # 954; B, and action Bacteroides thetaiotaomicron is bound to direct antagonism in relation to NF and # 954; B [95]. The found out mechanisms of antiinflammatory action L. reuteri consist in depression of synthesis IL-8, the main epithelial stimulator of migration of neutrophils that JUICE leads to reduction of inflammatory infiltration. Antiinflammatory effect L. reuteri bind also to concentration augmentation butirata of that in itself it is enough for cupping MKK, and in a number of researches its immediate influence on ENS and a motility has been proved. In experiment on mice T. Kamiya from co-workers. [121] observed inhibition of vegetative disturbances of a warm rhythm and depression of activity of ganglions of a back horn of the spinal cord, caused by a colon stretching, after reception

L. reuteri. The effect was observed at appointment both live, and the killed bacteria X. Ma from co-workers. [126] have shown, that preliminary reception within 9 days healthy mice L. reuteri reduces an action potential of ganglions of the back horn caused by a stretching of a colon. B. Wang from co-workers. [135] have shown, that reception by experimental animals L. reuteri reduces an intestinal motility and a hyperpolarization of muscular cells at the expense of inhibition Sa-activated

potassium channels. It became perceptible dozozavisimoe depression of activity of a motor complex of an intestine in reply to introduction of live bacteria. Killed L. reuteri and others laktobatsilly (L. salivarius) any effect did not render. Observable results, probably, speak influence L. reuteri on eisodic and efferent ways of a signal transmission enteral ganglions.

Efficiency of application L. reuteri at treatment MKK it is caused by antiinflammatory action, and also influence both on sensitivity and perception of a pain, and on regulation of the impellent answer. The given combination of several mechanisms influences major factors of pathogenesis MKK: disbioz, an inflammation, a hyperalgesia, allodiniju, motility disturbance. Influencing the given mechanisms probably to correct and other components of syndrome MKK: a hyperpermeability and JUICE, depression of a protective intestinal barrier, digestion disturbance, production of undesirable metabolites and gases.

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Scientific source KUBALOVA Saida Sultanovna. CLINICAL VALUE LAKTAZNOJ of INSUFFICIENCY And MICROBIC DISTURBANCES AT FUNCTIONAL DISORDERS of the GASTROENTERIC TRACT At CHILDREN of EARLY AGE. The dissertation on competition of a scientific degree of the candidate of medical sciences. St.-Petersburg - 2014. 2014

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Other medical related information Correction of infantile intestinal gripes:

  1. THE TABLE OF CONTENTS
  2. INTRODUCTION
  3. infantile intestinal gripes
  4. correction of infantile intestinal gripes
  5. the clinical characteristic of groups
  6. Chapter 7 DISCUSSION of RESULTS of RESEARCH
  7. CONCLUSIONS
  8. THE LITERATURE LIST
  9. THE LITERATURE LIST
  10. THE TABLE OF CONTENTS
  11. INTRODUCTION
  12. Infantile intestinal gripes
  13. Correction of infantile intestinal gripes
  14. the Clinical characteristic of groups
  15. Chapter 7 DISCUSSION of RESULTS of RESEARCH
  16. CONCLUSIONS
  17. THE LITERATURE LIST