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Clinico-laboratory indicators at treatment of a chronic arthritis with use of biological therapy

3.4.1. Correlation of clinico-laboratory indicators at children with JURA, receiving biological therapy

At carrying out of the correlation analysis level communication gepsidina with indicators of clinical and laboratory inflammatory activity of an arthritis is taped.

Strong positive correlation of level serumal gepsidina with quantity of the swelled up a little joints (r = 0,60) and quantity of painful joints (r = 0,71), and also with a blood sedimentation rate (r = 0,63) and very strong positive correlation with level of S-jet fiber (r = 0,87) is found out. Besides, level gepsidina very strongly it is positive
Correlates with quantity of leucocytes (r = 0,89) and thrombocytes (r = 0,89), and also strong positive correlation with absolute quantity of neutrophils (r = 0,79) becomes perceptible.

Also level communication gepsidina Serums with the indicators characterising a metabolism of iron in an organism becomes perceptible: very strong positive correlation with level of a ferritin of Serum (r = 0,90), average positive correlation with level of soluble receptors of a transferrin (r = 0,51), average negative correlation with level of iron of Serum (r =-0,49) and the general zhelezosvjazyvajushchej ability (r =-0,50) is defined.

Besides, communication of level serumal gepsidina with erythrocyte indexes becomes perceptible: strong negative correlation with average volume of an erythrocyte (r =-0,63) and with an average haemoglobin content in an erythrocyte (r =-0,62).

The indicators characterising correlation of clinico-laboratory indicators of children with juvenilnym by a pseudorheumatism are reflected in table 3.6.

Table 3.6.

Results of the correlation analysis of clinico-laboratory indicators at children with juvenilnym a pseudorheumatism, receiving biological therapy

Variables

n=20

PLAITS KBS ESR C-РБ Haemoglobin Erythrocytes MCV MCH MCHC Leucocytes AKN Thrombocytes rrtf Serum iron OZHSS Ferritin Gepsidin
PLAITS 1,00 0,75 0,55 0,64 -0,13 0,20 -0,37 -0,31 0,08 0,46 0,50 0,62 0,17 -0,28 -0,52 0,70 0,60
KBS 0,75 1,00 0,77 0,68 0,05 0,35 -0,40 -0,38 -0,05 0,66 0,54 0,76 0,23 -0,31 -0,56 0,83 0,71
ESR 0,55 0,77 1,00 0,64 0,13 0,23 -0,26 -0,26 0,08 0,58 0,54 0,56 0,10 -0,07 -0,40 0,70 0,63

Table 3.6.

(Continuation)
C-РБ 0,64 0,68 0,64 1,00 -0,11 0,40 -0,50 -0,55 -0,24 0,76 0,72 0,81 0,30 -0,39 -0,54 0,91 0,87
Haemoglobin -0,13 0,05 0,13 -0,11 1,00 0,43 0,27 0,21 -0,07 -0,08 0,03 -0,21 -0,12 0,31 0,27 -0,06 -0,15
Erythrocytes 0,20 0,35 0,23 0,40 0,43 1,00 -0,70 -0,78 -0,51 0,60 0,62 0,49 0,71 -0,47 0,16 0,35 0,43
MCV -0,37 -0,40 -0,26 -0,50 0,27 -0,70 1,00 0,94 0,20 -0,73 -0,66 -0,66 -0,81 0,73 0,17 -0,48 -0,63
MCH -0,31 -0,38 -0,26 -0,55 0,21 -0,78 0,94 1,00 0,50 -0,74 -0,69 -0,71 -0,83 0,69 0,01 -0,46 -0,62
MCHC 0,08 -0,05 0,08 -0,24 -0,07 -0,51 0,20 0,50 1,00 -0,27 -0,27 -0,31 -0,41 0,23 -0,36 -0,02 -0,10
Leucocytes 0,46 0,66 0,58 0,76 -0,08 0,60 -0,73 -0,74 -0,27 1,00 0,93 0,89 0,60 -0,66 -0,42 0,74 0,89
AKN 0,50 0,54 0,54 0,72 0,03 0,62 -0,66 -0,69 -0,27 0,93 1,00 0,77 0,52 -0,55 -0,37 0,65 0,79
Thrombocytes 0,62 0,76 0,56 0,81 -0,21 0,49 -0,66 -0,71 -0,31 0,89 0,77 1,00 0,55 -0,64 -0,37 0,80 0,89
rrtf 0,17 0,23 0,10 0,30 -0,12 0,71 -0,81 -0,83 -0,41 0,60 0,52 0,55 1,00 -0,64 0,16 0,24 0,51
Iron syv. -0,28 -0,31 -0,07 -0,39 0,31 -0,47 0,73 0,69 0,23 -0,66 -0,55 -0,64 -0,64 1,00 0,23 -0,32 -0,49
OZHSS -0,52 -0,56 -0,40 -0,54 0,27 0,16 0,17 0,01 -0,36 -0,42 -0,37 -0,37 0,16 0,23 1,00 -0,65 -0,50
Ferritin 0,70 0,83 0,70 0,91 -0,06 0,35 -0,48 -0,46 -0,02 0,74 0,65 0,80 0,24 -0,32 -0,65 1,00 0,90
Gepsidin 0,60 0,71 0,63 0,87 -0,15 0,43 -0,63 -0,62 -0,10 0,89 0,79 0,89 0,51 -0,49 -0,50 0,90 1,00

* Statistically significant indicators (p

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Scientific source EGOROV Andrey Sergeevich. THE GEPSIDIN-INTERLEUKIN-6 SYSTEM AS A FACTOR FOR MANAGING THE COURSE OF ANEMIA IN CHRONIC ARTHRITIS IN CHILDREN DISSERTATION for the degree of candidate of medical sciences. St. Petersburg - 2016. 2016

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Other medical related information Clinico-laboratory indicators at treatment of a chronic arthritis with use of biological therapy:

  1. THE TABLE OF CONTENTS
  2. INTRODUCTION
  3. Clinico-laboratory indicators at treatment of a chronic arthritis with use of biological therapy
  4. THE LITERATURE LIST
  5. INTRODUCTION