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Chapter 6 the COMPARATIVE ESTIMATION of EFFICIENCY of THERAPY of the SYNDROME of the ANGRY INTESTINE At CHILDREN

Within the limits of the given work and in conformity tasks in view, we have spent opened randomizirovannoe platsebo-supervised research of therapy SRK at children with use of various schemes. We have compared two therapeutic approaches - traditional, referred on correction of a motility and, considering the signs of an inflammation found out by us against the changed intestinal microbiocenosis, referred on microflora correction.

As a preparation regulating a motility, has been chosen trimebutin (Trimedat) which, influencing on opioidnye receptors GASTROINTESTINAL TRACT (is a blocker ts - both o-receptors and the activator of k-receptors), normalises the changed motility of an intestine and snizhet volume-threshold sensitivity of a colon. Trimebutin it was used in age dosages within 1 month (till 10 years - 50 mg 3 times a day; with 10 till 14 years - 100 mg 3 times a day; is more senior 14 years - 200 mg 3 times a day). We have compared efficiency various probiotikov: Lineks (containing not less than 1,2* 107 live liofilizirovannyh bacteria Bifidobacterium v. Liberorum, Lactobacillus acidophilus and Streptococcus faecium) on 1-2 capsule 2 times a day within 1 month; Enterolum (containing liofilizirovannye Saccharomyces boulardii) on 1-2 капсуле*2 once a day within 1 month; Rela Lajf (containing live laktobakterii Lactobacillus reuteri Protectis) on 1 chewing tablet once a day within 1 month. In quality prebiotika has been chosen Zakofalk (the combined preparation of oil acid and an inulin with immediate delivery of operating substances in a colon) on 1 tablet 3 times a day within 1 month. All children received a dietary food (a table № 4) during all period of medicamental treatment.

According to the chosen scheme of the treatment, all patients have been parted on 7 groups. The choice of type of therapy has been carried out by a random sample method:

1. Group (15 persons): Trimedat in an age dosage a course 1 month.

2. Group (20 persons): Rela Lajf in an age dosage a course 1 month.

3. Group (15 persons): Lineks in an age dosage a course 1 month.

4. Group (16 persons): Enterolum in an age dosage a course 1 month.

5. Group (20 persons): received the combined therapy prebiotikom (Zakofalk) in a combination with probiotikom in an age dosage a course 1 month.

6. Group (15 persons): received combined therapy Trimedatom in a combination with probiotikom in an age dosage a course 1 month.

7. Group (20 persons): received platsebo a course 1 month.

The estimation of efficiency of therapy was spent by comparison of the basic characteristics of a painful syndrome (a painful index), dispepsicheskih disturbances - abdominal distentions and frequencies of a chair (dispepsichesky an index), level fecal kalprotektina, indicators of the hydrogen respiratory test and feces crops on a dysbacteriosis, and also visceral hypersensitivity of a rectum before treatment.

6.1

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Scientific source TIPIKINA Maria Jurevna. ESTIMATION of the ROLE of INFLAMMATORY And MICROBIOLOGICAL CHANGES AT the SYNDROME of the ANGRY INTESTINE At CHILDREN. The dissertation on competition of a scientific degree of the candidate of medical sciences. St.-Petersburg - 2014. 2014

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Other medical related information Chapter 6 the COMPARATIVE ESTIMATION of EFFICIENCY of THERAPY of the SYNDROME of the ANGRY INTESTINE At CHILDREN:

  1. THE TABLE OF CONTENTS
  2. Chapter 6 the COMPARATIVE ESTIMATION of EFFICIENCY of THERAPY of the SYNDROME of the ANGRY INTESTINE At CHILDREN
  3. Chapter 7 DISCUSSION of RESULTS of RESEARCH