CHAPTER 8. FEATURES OF TREATMENT OF CHILDREN SICK OF THE TUBERCULOSIS AND A HIV BY A-INFECTION

Main principles of treatment of children sick of a tuberculosis and a HIV - by an infection, same, as well as children sick of a tuberculosis without a HIV-infection. The chemotherapy should be the basic component of complex treatment sick of a tuberculosis, sochetannym with a HIV-infection.

However odnovremenyonoe treatment of a tuberculosis and a HIV-infection becomes complicated medicinal interactions, especially between an antituberculous preparation riyofampitsinom and antiretrovirusnymi preparations (ARVP) two classes - neyonukleozidnyh inhibitors of return transkriptazy (NNIOT) and ingibitoyorov HIV proteases (IP). Rifampicin is a powerful inductor цито�хромаP450 (CYP450) which accelerates splitting IP and some NNIOT, therefore in case of simultaneous application of their concentration in a blood plasma can fall to subtherapeutic levels, that in the ocheyored can lead to intensifying replikatsii a HIV and corresponding otyosutstviju effect from antiretrovirusnoj to therapy (art). In these cases the adult patient prescribe rifabutin which allows to avoid leyokarstvennyh interactions, but to children, especially early age the preparation is not recommended in the absence of children's medicinal forms and vozmozhyonyh collateral reactions [130].

Besides, the choice of scheme art for children with a HIV-infection and tuberkuyolezom is complicated because of small amount ARVP, having children's leyokarstvennye forms, otsutstvijadlja data some of them on dosages at children (especially at children is more younger 3 years) on the one hand, and age ogyoranicheniem includings of some antituberculous preparations in reyozhimy chemotherapies - on the other hand.

All these features very often lead to that is necessary inyodividualizirovat chemotherapy regimens at treatment of children.

<< | >>

↑

Scientific source KLEVNO HOPE IVANOVNA. TUBERCULOSIS At CHILDREN, SICK HIV-INFECTIONS (prevalence, features of clinical implications, diagnostics, treatment, preventive maintenance). The dissertation on competition of a scientific degree of the doctor of medical sciences. Moscow - 2015. 2015

��

Other medical related information CHAPTER 8. FEATURES OF TREATMENT OF CHILDREN SICK OF THE TUBERCULOSIS AND A HIV BY A-INFECTION:

- Pediatrics -

- Biological Sciences - Biomedical Sciences - Clinical medicine - Field medicine - Infectious diseases - Medical devices - Oncology - Pediatrics - Pharmaceutical Sciences - Psychology - Pulmonology - Stomatology - Traumatology and orthopedics -