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Chapter 5 Discussion of the received results

Mucoviscidosis consider typical monogene, autosomnoyoretsessivnym as genetic disease. According to the International consortium on a mucoviscidosis disturbance of pancreatic function at patients MV is closely bound with MVTR a genotype.

poliorgannost lesions at MV, low life expectancy of patients, an early invalidism dictate necessity of constant carrying out of medical actions and a dispensary observation. In the developed countries last years growth of number of patients MV of teenage, youthful age and adults that testifies to its gradual transformation from fatal disease of children's age in a chronic pathology of adults [36, 40, 41, 111, 122] becomes perceptible.

In a current of 3 summer observations over children sick of a mucoviscidosis, it has been established: absence of dependence of indicators of ventilating function of lungs from a floor and age (p> 0,05), but their interrelation with gravity of a current of disease has been taped.

At carrying out of genetic inspection at patients observed by us in half of cases have been defined: a homozygote on a mutation Delta F508 - n = 25 (31 %) and a heterozygote on a mutation Delta F508 - n = 18 (22 %). Rare mutations - n = 17 (21 %) and an unknown mutation - n = 21 (26 %) met equally often.

The majority of observable children were with the admixed form from a mucoviscidosis (82,7 %) and a moderately severe current (53 %). The patients having primary implications from a gastroenteric tract or lungs, met seldom (on 7,5 %; 9,8 % - accordingly). With an easy current of a mucoviscidosis there were only 9 % of children, with a serious current - 38 %.

To thicket children arrived in the period of an exacerbation of disease (63 %), 37 % - in the remission period, 79 children have arrived repeatedly.

Technical simplicity and brevity of performance of procedure of research have allowed to spend for the first time an estimation of ventilating disturbances by a method bronhofonografii at children from 2 months till 5 years. A method of an impulsive oscillometry have estimated a functional condition of bronchuses in 69 % of cases. The spirometry is executed at children is more senior 4 years in 67 % from the observed. The method bodipletizmografii makes an estimation of ventilating function of lungs at 36 % of children. Research of gas structure arterializirovannoj bloods has been spent at all children observed by us from 2 months till 18 years.

For the period of remission at children with an easy current of a mucoviscidosis absence of disturbances of bronchial passableness is characteristic. At srednetjazhelom a current only at two children moderate disturbances of passableness of peripheric bronchuses became perceptible. Low high-speed indicators have been taped at children with serious current MV (p

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Scientific source TARASOVA OLGA VLADIMIROVNA. Ventilating function of lungs at children sick of a mucoviscidosis, at the present stage. The dissertation on competition of a scientific degree of the candidate of medical sciences. Moscow - 2014. 2014

Other medical related information Chapter 5 Discussion of the received results:

  1. THE TABLE OF CONTENTS
  2. the Table of contents
  3. Chapter 4 Discussion of the received results
  4. THE TABLE OF CONTENTS
  5. Chapter 7 DISCUSSION of RESULTS of RESEARCH
  6. the Maintenance:
  7. CHAPTER 8. THE CONCLUSION (DISCUSSION OF THE RECEIVED RESULTS)
  8. INTRODUCTION
  9. CHAPTER №5 DISCUSSION
  10. the Table of contents
  11. Chapter 5 Discussion of the received results
  12. Chapter 7 DISCUSSION of RESULTS of RESEARCH
  13. THE TABLE OF CONTENTS
  14. CHAPTER 4. THE CONCLUSION (DISCUSSION OF THE RECEIVED RESULTS)