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1.2 Anemia at chronic illnesses

In 1932 Locke, etc. have made the important observation, that the infection associates with the low maintenance of serumal iron is partially explained frequent detection of an anaemia at patients with chronic infections [148].

Cartwright and Wintrobe have gone further and have established, that the anaemia bound to an infection is indistinguishable from an anaemia at inflammatory diseases and is caused by absorption of iron by cells of reticuloendothelial system and disturbance of an absorption of iron in an intestine [36]. They have offered for the first time the term an anaemia at chronic illnesses [35]. Cartwright and Lee have shown, that similar implications can develop at mice under the influence of a bacteriemic endotoxin [34]. Further it has been shown, that the anaemia at chronic illnesses is bound to action of proinflammatory cytokines and their action on a metabolism of iron [152]. Cytokines modulate export of iron from cells and its accumulation in cells of reticuloendothelial system [43]. Last years many researchers have converged that gepsidin plays a key role in development gipoferremii and anemias at an inflammation [96,112,218]. It has been besides, shown, that ИЛ-6 operates immediately on hepatocytes, stimulating formation gepsidina which, in turn, represents itself as a negative regulator of an absorption of iron in an intestine and its exit from macrophages [107]. Because at patients with acute or chronic activation of immune system development of an anaemia with signs AHB becomes perceptible it is offered to designate the given condition as an inflammation anaemia [151]. However, for today, in the International classification of illnesses (МКБ-10) the given condition is designated as an anaemia at the chronic illnesses classified in other headings (D63).

AHB the second is for prevalence after an iron deficiency anaemia. The most widespread conditions bound to development AHB are presented in table 1.1. [245]. At older persons (65 years also are more senior) AHB surpasses ZHDA in prevalence [186].

Table 1.1.

The principal causes underlying development of an anaemia of chronic disease

Assotsiirovannye diseases Prevalence
Infections (acute and chronic)

Virus infections, including a human immunodeficiency virus

The bacteriemic

The parasitogenic

Mycoses

18-95 %
Oncologic diseases

Hemoblastoses

Solid tumours

30-77 %
Autoimmune diseases

Pseudorheumatism

System lupus erythematosus and other diseases of a connecting tissue

Vasculites

Sarcoidosis

Inflammatory diseases of an intestine

8-71 %
Chronic reaction of a graft rejection 8-70 %
Chronic diseases of kidneys 23-50 %

1.2.1.

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Scientific source EGOROV Andrey Sergeevich. THE GEPSIDIN-INTERLEUKIN-6 SYSTEM AS A FACTOR FOR MANAGING THE COURSE OF ANEMIA IN CHRONIC ARTHRITIS IN CHILDREN DISSERTATION for the degree of candidate of medical sciences. St. Petersburg - 2016. 2016

Other medical related information 1.2 Anemia at chronic illnesses:

  1. THE TABLE OF CONTENTS
  2. 1.2 Anemia at chronic illnesses
  3. bases of a pathogenesis of an anaemia at chronic illnesses
  4. anaemia diagnostics at chronic diseases
  5. THE CONCLUSION
  6. CONCLUSIONS
  7. PRACTICAL REFERENCES
  8. THE LITERATURE LIST
  9. a spectrum of diseases at which (or in which outcome) the long subfebrile condition
  10. THE LITERATURE LIST
  11. 2.1 General clinical characteristic of surveyed children.