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an aetiology and pathogenesis JUIA.

Aetiology JUIA remains maloizuchennoj till now. JUIA is autoimmune disease with a polygenic mode of inheritance in which development take part a number hereditary and sredovyh factors among which certain value is given to an infection.

The most frequent factors starting the mechanism of a course of a disease, traumas of joints, an insolation or a frigorism, the bacterination especially spent against or right after transferred infection [10, 119,125] are a virus or is bacteriemic-virus infection.

A series immunogeneticheskih works has taped communication juvenilnyh arthritises with antigens gistosovmestimosti HLA. Associations HLA V27 with predisposition to development of an ankylosing spondylitis, a reactive arthritis are Most widely known. Rising of frequency of antigens gistosovmestimosti I class - А2, В27, В35 - has been taped at children with JUIA as a whole in various works. Also, it became known, that antigen А2 assotsiirovan mainly with the early beginning oligoartirita at girls. Genetic associations with antigens of II class are more numerous and are combined with various types of the beginning and current JUIA in comparison with antigens of I class. The most frequent association JUIA with antigens gistosovmestimosti HLA DR-5, DR-8, DR-1 is taped. During too time DR-2 and DR-7 are specified as the antigens of II class meeting authentically is more rare at patients JUIA, than in population, and can be surveyed as protective markers. [125,129]

Pathogenesis JUIA, as well as at other autoimmune diseases, is combined. There is a number of the hypotheses explaining the basic pathogenetic aspects of the autoimmune nature of rheumatological diseases. According to a hypothesis of a molecular mimicry disease can be caused antigenic components of some microorganisms reminding on a structure own antigens, including antigens gistosovmestimosti. The antibodies developed in reply to introduction of infectious agents, in this case become antibodies to own HLA-antigens. These antibodies contact HLA-molecules which are to the greatest degree expressed on lymphocytes, fibroblasts, chondrocytes. Then there is an activation komplementarnogo the cascade that conducts to development of inflammatory process and occurrence of clinical symptoms of disease [10,125,129,147].

The basic postulate of a "receptor" hypothesis consists that T - cells have receptor molecules which allow them to distinguish foreign antigens in a combination with own molecules of the main complex gistosovmestimosti on the surface. At autoimmune disease the immune system becomes sensibilizirovannoj to own
To antigens; as a result of the mediated influence activated T - lymphocytes and autoantibodies in an organism there are cellular damages [10,72,125].

As a result of realisation of pathological process, in an organism, the superfluous quantity of proinflammatory cytokines is formed.

The central inflammatory cytokines underlying a rhematoid inflammation are - the factor of a necrosis of a tumour and (FNO-), interlejkiny (SILT)-2, 1, 6 [4,17-19,39,76,124]. The role FNO - and in development of rheumatic diseases, including JUIA, juvenilnogo an ankylosing spondylitis (JUAS) [55] is Most well studied. With FNO - and bind such effects as activation of neutrophils, T and V-limfotsitov, an induction of synthesis IL-2, interferon scale - activation of macrophages, an induction of synthesis IL 6, development of a chronic inflammation, a destruction of a cartilage and loss of an osteal tissue, development of the inflammatory answer (a fever, a pain, loss of weight, etc.), contribution to formation ostrofaznyh inflammatory fibers (SRB, a seromucoid, etc.), an induction (regulation) of an expression of intercellular molecules of adhesion and others [4,30,64,88,99].

As a result of the processes set forth above in a clinical picture of disease those or other implications prevail. JUIA it is characterised by mainly destructive lesion of joints, and also a pathology of other organs and tissues with formation of multiorgan insufficiency of various degree of expression [10,117,125,147].

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Scientific source Loskutova Olga Jurevna. Efficiency and safety of genno-engineering biological preparations (infliksimab, etanertsept, abatatsept) at children with various variants juvenilnogo an idiopathic arthritis. The DISSERTATION on competition of a scientific degree of the candidate of medical sciences. Moscow - 2014. 2014

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Other medical related information an aetiology and pathogenesis JUIA.:

  1. THE TABLE OF CONTENTS
  2. INTRODUCTION
  3. introduction
  4. an aetiology and pathogenesis JUIA.