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THE TABLE OF CONTENTS

P.

INTRODUCTION............................................................................................................ 4

Chapter 1. The LITERATURE REVIEW

1.1. Chemical structure and the action mechanism

bisfosfonatov......................................................................................................

11

1.2. A pathogenesis, diagnostics, treatment and preventive maintenance bisfosfonatnogo

Osteonecrosis of jaws......................................................................................... 18

Chapter 2. MATERIALS And RESEARCH METHODS

2.1. A general characteristic of patients.................................................................. 32

2.2. The clinical characteristic of patients........................................................ 34

2.3. A pain estimation.................................................................................................. 36

2.4. Radial methods of inspection.................................................................... 37

2.5. Methods of immunologic research................................................. 38

2.6. Morphological research.................................................................. 44

2.7. Equipment and a technique of carrying out of local ozonotherapy....................... 46

2.8. Equipment and a technique of reception of a blood plasma of patients..................... 49

2.9. Statistical processing of the received

Results........................................................................................................... 51

Chapter 3. RESULTS of OWN RESEARCHES

3.1. Results of clinical inspection of patients c bisfosfonatnym

Osteonecrosis of jaws...................................................................................... 53

3.2. Results of radiological inspection of patients c bisfosfonatnym

Osteonecrosis of jaws...................................................................................... 62

3.3. Results of treatment sick c bisfosfonatnym an osteonecrosis

Jaws............................................................................................................... 71

3.4. Results morphological and morfometricheskogo researches...... 103

3.5. Development preventive maintenance bisfosfonatnogo an osteonecrosis of jaws......... 115

Chapter 4. DISCUSSION of RESULTS OWN

RESEARCHES............................................................................................ 127

CONCLUSIONS........................................................................................................... 137

PRACTICAL REFERENCES............................................................ 139

THE LIST OF REDUCTIONS................................................................................ 141

THE LITERATURE LIST................................................................................. 142

APPENDICES................................................................................................. 165

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Scientific source ZASLAVSKAYA NATALIA ALEKSANDROVNA. OPTIMIZATION of PREVENTIVE MAINTENANCE And TREATMENT BISFOSFONATNYH of OSTEONECROSES of JAWS At PATIENTS WITH MALIGNANT NEOPLASMS. The dissertation on competition of a scientific degree of the candidate of medical sciences. Moscow - 2014. 2014

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