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a general characteristic of patients

From 2009 for 2013 on the basis of TSS and CHLH MGMSU of A.I.Evdokimova we had been surveyed and spent treatment of 75 patients having in the anamnesis intravenous therapy bisfosfonatami in connection with presence of malignant neoplasms, from which 53 women and 22 men at the age from 32 till 78 years (Table 2).

Among the addressed patients the jaw osteonecrosis has been diagnosed for 60 persons, 15 patients were for the purpose of carrying out of surgical sanation of an oral cavity.

Treatment of patients was spent on chair of maxillofacial surgery and chair of geriatric stomatology MGMSU of A.I.Evdokimova.

Table 2

Distribution of patients on a floor and age

Age group Men Women
n % n %
30-39 years 0 0 1 1,33
40-49 years 1 1,33 6 8,0
50-59 years 4 5,33 11 14,67
60-69 years 8 10,67 23 30,67
70-79 years 9 12,0 12 16,0
IN TOTAL 22 29,33 53 70,67

All patients for a long time (from 8 months till 5 years) received monthly intravenous introduction bisfosfonatov on a basis

zolendronovoj acids (Zometa, Zoleriks) in connection with presence of osteal metastasises of various malignant neoplasms (the Drawing 3).

Fig. 3. The chart. Distribution of patients with bisfosfonatnym an osteonecrosis of jaws on a basic disease.

The diagnosis «Bisfosfonatnyj a jaw osteonecrosis» was established according to the criteria offered by the American association of surgeons-stomatologists and maxillofacial surgeons, being conventional in the world:

1. Presence of sites of the bared osteal tissue in an oral cavity or is long not healing small cavities of a remote teeth throughout more than 8 weeks.

2. Presence in the anamnesis at the patient of intravenous therapy bisfosfonatami.

3. Absence in the anamnesis at the patient of radial therapy in cheljustnoyolitsevoj areas (for an exception of the diagnosis of a radial osteonecrosis of a jaw).

At all addressed patients carrying out of antitumoral therapy on a basic disease proceeded.

Patients have been parted on 3 groups depending on methods treatments (Table 3).


Table 3

Distribution of patients on research groups

1 group (with ozonotherapy) 2 group (control) 3 group (the patients requiring carrying out of surgical sanation)
n % n % n %
M 12 16,0 7 9,33 5 6,67
26 34,67 15 20,0 10 13,33
IN TOTAL 38 50,67 22 29,33 15 20,0

The first group of research «conservative treatment with application of local ozonotherapy» consisted of 38 patients with bisfosfonatnym an osteonecrosis of jaws at the age from 32 till 78 years. To patients of the given group the conservative treatment including monthly courses of ozonotherapy in the field of an osteonecrosis was spent.

The second "control" group of research included 22 patients with bisfosfonatnym an osteonecrosis of jaws at the age from 49 till 76 years by which conservative treatment of an osteonecrosis without ozonotherapy application was spent.

The third group of research consisted of 15 patients at the age from 45 till 67 years requiring carrying out of surgical sanation of an oral cavity concerning complicated caries, having in the anamnesis intravenous therapy bisfosfonatami on a basis zolendronovoj acids and, accordingly, having high risk of development of an osteonecrosis of a jaw.

2.2.

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Scientific source ZASLAVSKAYA NATALIA ALEKSANDROVNA. OPTIMIZATION of PREVENTIVE MAINTENANCE And TREATMENT BISFOSFONATNYH of OSTEONECROSES of JAWS At PATIENTS WITH MALIGNANT NEOPLASMS. The dissertation on competition of a scientific degree of the candidate of medical sciences. Moscow - 2014. 2014

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