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Etiology

The novel coronavirus (termed as COVID-19 by World Health Organization) belongs to the coronavirus β genus, which is encapsulated in round or oval shape, and 60-140mm in diameter. The genetic characteristics of COVID-19 are significantly different from SARS-CoV and MERS-CoV It shares more than 85% homology with SARS-Iike coronavirus isolated from bat (bat-SL-CoVZC45).

The COVID-19 can be detected in human respiratory epithelial cells for about 96 hours in vitro, but it takes about 6 days to isolate and culture in Vero E6 and Huh-7 cell lines.

Our current understandings on the biochemical features of COVID-19are mostly derived from previous studies on SARS-CoV and MERS-CoV COVID-19 is fragile to ultraviolet and heat (56 oC for 30 minutes). It can also be inactivated by Iiposoluble solvents, such as ether, 75% ethanol (w∕v), chlorine-containing disinfectant and chloroform. However, Chlorhexidine has been proved generally ineffective.

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Scientific source Chinese Clinical Guidance for COVID-19 Pneumonia Diagnosis and Treatment (7th edition) (published by China National Health Commission on March 4,2020). 2020

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  13. Conclusions under chapter 1