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Introduction

Theme urgency. The increase in number of cases of pathologies of body of sight and determination of the physical inability connected with it causes necessity of perfection of methods and hardware-software diagnostic aids and therapy of ophthalmologic diseases.

One of the priority directions of such perfection is working out of production engineering of diagnostic of a condition of various departments of blood system of an eye.

Methods applied in modern clinical practice allow to size up a condition of separate vessels retrobulbarnogo or back departments of an eyeball, various departments of a retina, but do not allow to size up in a complex a blood-groove in vessels, small arteriolah and prekapilljarah fast-head department of an eye that has essential value for diagnostic miopii, atherosclerosis and of some other diseases, both ophthalmologic, and system character.

One of the methods, allowing to investigate haemodynamics of fast-head department of an eye - the method developed in the middle of the last century reooftalmografii. Its application is connected with conducting of contact measurements prilimbarno (on an open eye of the patient), that causes necessity of conducting of a double anaesthesia, preliminary biometric research of an eye, and also the raised marks infitsirovanija and travmirovanija eyes in the course of diagnostic study. Besides, absence of special methods and algorithms of machining of the information complicates a support of adoption of diagnostic solutions at conducting reooftalmologicheskih researches, especially at children.

The priority direction of elimination of noted deficiencies reooftalmografii is conducting of research of haemodynamics of fast-head department of an eye transpalpebralno (through the closed eyelid). However special mathematical and the software of such researches with the quality, to fulfilling requirements of modern ophthalmologic practice, prior to the beginning of researches has not been developed.

The executed work is continuation of researches and workings out of hardware-software diagnostic aids of pathologies of system of blood circulation of the eye, the executed A.J.Buninym (1990), K.E.Kotljarom (2006), G.A.Drozdovoj (2007), A.M.Shamshinovoj (2010); reografii, the foreign representatives foreign, Soviet and Russian scientific schools (Polzer, 1950; Schuhfried, 1950; Jenker, 1957; H.H.Jarullin, 1967; J.E.Moskalenko, 1970; G.I.Eninja, 1973;

A. I.Naumenko, 1975; V.V.Skotnikov, 1975; S.I.ShChukin, 1988-2016, etc.) and

reooftalmografii, L.A.Katsnelson, 1966, 1990; V.I.Kozlov, 1972;

B. I.Lazarenko, 2000, etc.). However conducting possibility reooftalmografii transpalpebralno (through an eyelid) in known domestic and foreign samples reooftalmograficheskoj equipments is absent, that defines an urgency of work which consists in working out of special mathematical, programm and apparatus maintenance of the automated gathering and information machining at transpalpebralnyh reooftalmograficheskih researches.

The work purpose is the possibility of research of haemodynamics of fast-head department of an eye with use of a noninvasive technique transpalpebralnoj reooftalmografii at the expense of working out and implementation special mathematical and the software of machining of the information.

For purpose achievement following research problems are solved:

1.

The architecture of a bioengineering system transpalpebralnoj reooftalmografii, providing noninvasive research of haemodynamics of fast-head department of an eye is proved.

2. The base mathematical model is developed for research of haemodynamics of fast-head department of an eye on a basis transpalpebralnoj reooftalmografii.

3. The teoretiko-experimental substantiation of informative parametres of a condition of haemodynamics of fast-head department of an eye for use is executed
Results transpalpebralnoj reooftalmografii at diagnostic of ophthalmologic diseases.

4. Are developed and realised mathematical, programm and hardware for noninvasive research of system of blood circulation of fast-head department of an eye and a decision-making support at diagnostic of ophthalmologic diseases.

Scientific novelty of work. In the dissertation the following results characterised by scientific novelty are gained.

1. Architecture of the problemno-oriented bioengineering system reooftalmografii, differing use tetrapoljarnoj systems of assignments at transpalpebralnom (through an eyelid) research.

2. Mathematical electrophysical three-dimensional model of an eye with the additional apparatus, differing from characteristics of eight layers of an eyeball earlier known for account and two layers of cloths surrounding it.

3. Algorithm of calculation of shock volume of blood circulation for fast-head department of an eye with use tetrapoljarnoj reooftalmografii.

The practical significance of work is defined by that developed special mathematical and the software provides possibility of research of haemodynamics of fast-head department of an eye with use of a noninvasive technique transpalpebralnoj

reooftalmografii, allowing to expel necessity of a double anaesthesia, it is essential to simplify research procedure, to carry out researches at patients at the age from 5 years, to size up an absolute a value of shock volume of blood in fast-head department of an eye, allows to carry out differential diagnostic with use of the gained information.

Methodology and research methods. For the solution of tasks in view methods were used: theories of bioengineering systems of medical appointment, mathematical statistics, control theory, the theory of the linear electric
Chains, mathematical modelling. The software has been developed in the environment of Delphi 7.

The rules which are taken out on protection:

1. The bioengineering system transpalpebralnoj reooftalmografii, providing noninvasive research of haemodynamics of fast-head department of an eye, should be realised in the form of a knitted helmet with korsazhnoj a tape which is adjusted under any grasp of a head, and the electrode system had on an emulsion carrier anatomicheski of the optimised form and using tetrapoljarnuju system of assignments.

2. The mathematical electrophysical three-dimensional model of an eyeball and its additional apparatus, merging eight layers of an eyeball and two layers of cloths surrounding it taking into account geometrical characteristics of an eye and system of electrodes, is base haemodynamics for research of fast-head department of an eye on a basis transpalpebralnoj reooftalmografii.

3. The impedance parametre characterising magnitude and speed of inflow (outflow) of blood in fast-head department of an eye taking into account arterial pressure, and shock volume of blood are informative parametres of a condition of haemodynamics of fast-head department of an eye by results transpalpebralnoj reooftalmografii.

Reliability of the gained results proves to be true results of the spent approbation and verification of results by employees of department of a pathology of a refraction, a binocular sight and oftalmoergonomiki and department of ultrasonic researches of the Moscow scientific research institute of eye sicknesses it. Gelmgoltsa in groups of patients an aggregate number of 116 persons.

Implementation of results of researches. Developed apparatnoyoprogrammnye means and methodical recommendations of research of haemodynamics of fast-head department of an eye on a basis transpalpebralnoj reooftalmografii are introduced in clinical practice MNII of eye sicknesses by It. Gelmgoltsa
(Moscow) and in Private Establishment of Public health services «Medicosanitary part» (Astrakhan).

The personal contribution of the author: results are gained by the author personally, the cores from them are: working out and implementation technical, mathematical and software of the problemno-oriented bioengineering system, working out of mathematical model of an eyeball and its additional apparatus, the mathematical description of vascular structures of an eye, working out of algorithm of calculation of shock volume of blood of fast-head department of an eye, statistical machining of results of measurements and the expert information gained during researches.

Approbation of results. Results of dissertational work were reported and discussed at the international scientific conference «МЕТРОМЕД-2011» (St.-Petersburg, 2011), at 6th Russian national ophthalmologic forum (Moscow, 2013), at 7th Russian national ophthalmologic forum (Moscow, 2014), on 7­й the All-Russia conference "Biomechanics" (Perm, 2014), at conference «Innovative production engineering in ophthalmologic practice of regions» (Astrakhan, 2014), on 10th cross-over of ophthalmologists of Russia (Moscow, 2015), on 11 All-Russia cross-over on fundamental problems of theoretical and applied mechanics (Kazan, 2015), at 8th Russian national ophthalmologic forum (Moscow, 2015), at 9th Russian national ophthalmologic forum (Moscow, 2016), on 18th nauchnoyotehnicheskoj conferences «МЕДТЕХ-2016» (Moscow, 2016), At conference «European Medical and Biological Engineering Conference (EMBEC) and the Nordic - Baltic Conference on Biomedical Engineering and Medical Physics (NBC) 2017» (Tampere, 2017).

By results of research 19 scientific works, 11 of which - in the publications recommended VAK at Minobrnauki to Russia are published, 2 patents for useful models are gained.

Work is executed at a support of the grant of the Russian Federal Property Fund №13-08-01079 «Working out and research of a noninvasive method of diagnostic of a blood-groove of an eye with use tetrapoljarnoj impedance pletizmografii» and the Russian Federal Property Fund grant № 15-08-99682 «Working out and research of a method of therapeutic affecting on haemodynamics of an eye with a simultaneous estimation of efficiency on parametres of an eye blood-groove».

Structure and dissertation volume. Dissertational work consists of the introduction, four heads, leading-outs and applications. The basic maintenance of work is stated on 173 pages, contains 94 drawings, 11 tables; the literature list switches on 105 sources, from them 22 foreign.

The author expresses sincere gratitude of the prof., d.t.n. The paratyre of Century B for the offered idea of development of a method reografii for ophthalmology, to employees of faculty "Bioiatrotechnics" of MGTU of AD Bauman and personally to the dean

Faculty of the prof., d.t.n. S.I.Schukin for constructive criticism of materials of the dissertation, to colleagues from Open Company «ATES the PHYSICIAN a software», and also the prof., d.b.n.

To E.N.Iomdinoj and other employees of the Moscow scientific research institute of eye sicknesses it.

Gelmgoltsa for the help and consultations at conducting of some researches.

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Scientific source SHAMAEV DMITRY MIHAJLOVICH. BIOENGINEERING SYSTEM of RESEARCH of HAEMODYNAMICS of the EYE With USE transpalpebralnoj REOOFTALMOGRAFII. The dissertation on competition of a scientific degree of a Cand.Tech.Sci. Moscow - 2017. 2017

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