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Supraspinalnyj level

Target of action of exciting amino acids on suprasegmentarnom level is central okolovodoprovodnoe material (TSOV), whence through BJASH there are descending pathes to a spinal cord to structure zadnelateralnogo a cord (Behbehani, Fields, 1979).

Injections of exciting amino acids in TSOV lead expressed analgezii (Behbehani, Fields, 1979). This effect of exciting amino acids is mediated by specific receptors as it is quenched glutamatnymi by antagonists (Jacquet, 1988). Microapplication morfina in TSOV also enhances neural activity in BJASH and possesses analgeticheskim action (Behbehani, Fields, 1979).

The essential contribution to regulation of pain sensations leads and descending regulating system. So introduction glutamata in ATN regulates transfer of pain sensations at spinal level (Urban, Gebhart, 1997; Zhuo, Gebhart, 1992). Introduction of the antagonist of NMDA-receptors APV depresses development of processes of damage at spinal level and development secondary giperalgezii
At use of experimental model of an inflammatory pain (Urban et al., 1999).

NR2B The subunit is located in the specific frames TSNS playing a key role in processes of perception of a pain (a lobby zone and ostrovkovaja a neoncephalon cortex). Also this subunit can settle down out of synapses and involve in process of a chronic pain ekstrasinaptichesky glutamat, increasing «excitoxicity» (Petrenko et al., 2003). It is Besides, shown, that the selective antagonists reacting mainly on subunit NR2B render antinotsitseptivnyj effect which is caused by primary influence on supraspinalnye the frames, participating in descending regulation of pain sensations (Chizh, 2001).

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Scientific source MALYSHKIN Andrey Anatolevich. ROLE of GLUTAMATERGICHESKY SYSTEM In PROCESSES of the SHARP And CHRONIC PAIN. The DISSERTATION on competition of a scientific degree of the candidate of medical sciences. St.-Petersburg 2006. 2006

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