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experiences with ingibitorami enzyme glutamil karboksipeptidazy (GPI 5693, GPI16072, RMRA)

Procedure of selection of animals before operation corresponded described above in section 2.7.1. Tests with materials spent, since fourteenth postoperative day.

In experiences with RMRA for 11th postoperative day estimated level tactile allodinii then animal who corresponded to criteria of selection, carried out implantation intravenous katetera in right jaremnuju a vein (see above in section 2.4.4).

The first test with introduction of pharmacological agents spent for 3rd day after implantation intravenous katetera (14th day after sciatic nerve bandaging).

After that tests with materials spent twice a week. An animal introduced investigated materials in the event that the difference of thresholds of tactile reactance between paws exceeded 10 the Order of tests with various doses of materials has been balanced under the scheme "Latin square".

In each experimental day spent 9 tests: before introduction of a preparation and in 15, 30, 45, 60, 90, 120, 150 and 180 minutes after introduction of material or its solvent. Each measurement of a threshold of tactile reactance repeated on the same animal in 2 minutes (Chen et al., 2002). Following doses of material have been tested: 0 (N=9), 25 (N=12), 50 (N=10) and 100 (N=10) mg/kg. A preparation introduced intravenously.

For materials GPI 5693 and GPI 16072 in each experimental day spent 4 tests: before introduction of a preparation and in 1, 2 and 3 hours after introduction of material or its solvent. Following doses of materials have been tested: GPI 5693 (10, 30, 100 mg/kg) and GPI 16072 (1, 3 and 10 mg/kg). Preparations introduced peroralno daily throughout 22 days. Effects of various doses of materials investigated on separate bunches of animals.

2.7.7.

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Scientific source MALYSHKIN Andrey Anatolevich. ROLE of GLUTAMATERGICHESKY SYSTEM In PROCESSES of the SHARP And CHRONIC PAIN. The DISSERTATION on competition of a scientific degree of the candidate of medical sciences. St.-Petersburg 2006. 2006

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