discussion of results
It is shown, that after sdavlenija a sciatic nerve ligaturami at animals marked number augmentation альфа2л adrenoretseptorov and reduction альфа2с adrenoretseptorov in spinal cord horns (Shi et al., 2000), that, however, is not marked at the inflammatory mechanism of development of a pathological pain (Janig et al., 1996).
Solvent
Gabapentin 30 mg/kg
To 1 2 3 To 1 2 3 To 1 2 3 To I 2 3 To 1 2 3 To 1 2 3 To 1 2 3
Day 1 Day 4 Day 8 Day 11 Day 15 Day 18 Day 22
Fig. 3.15. Influence gabapentina on tactile allodiniju at rats. On an extent of 22 days an animal introduced gabapentin (30 or 100 mg/kg) or its solvent peroralno. Control tests carried out for 1st, 4th, 8th, 11th, 15th, 18th and 22nd day of daily introduction of material. Tactile allodiniju estimated before introduction (dark figures) and in 1, 2 and 3 hours after introduction (light figures) material or its solvent (‘ To ’, ‘ 1 ’, ‘ 2 ’ and ‘ 3 ’, accordingly). Data are presented as average value of a threshold otdergivanija paws (Myot). Squares - the operated paw, mugs - lozhnooperirovannaja a paw.
Table 3.15. Data of dispersive analysis of influence GPI 5693 and GPI 16072 on development and exhibiting tactile allodinii.