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damage of peripheral nerves

Formation model nevromy. At carrying out of ablation of nerve fibril on proksimalnom the nerve end it is formed nevroma, consisting of processes it is superfluous recycling nerve fibrils. The given model is characterised by the greatest frequency of occurrence autotomii, but allodinija and giperalgezija are not expressed almost.

For ethical reasons this model has the circumscribed application (Seltzer et al., 1990; Zeltser et al., 2000).

Model chronic sdavlenija a nerve (Bennet's model and This). Carry out by imposing poorly fastened ligatur on a sciatic nerve. Is most often used model as it is simple enough in execution and it is thus characterised by presence of all signs nejropaticheskoj pains (Bennett, Xie, 1988).

Model of particulate bandaging of a sciatic nerve (model Selttsera). Is paravariation previous and it is based on particulate bandaging of a sciatic nerve at level of the top part of a femur. A nerve stitch and tie up on ’ L - Ouse from the general thickness of a sciatic nerve. Also it is characterised by presence of all signs nejropaticheskoj pains. Advantage of model is conservation of the specified signs within 7 months unlike the previous model (till 2 months) (Seltzer et al., 1990).

Model of bandaging of backs of a spinal cord (Chang's model). At bandaging or pererezke spinal cord backs (L5 and (whether) L6) distalnee level of spinal ganglions signs nejropaticheskoj pains (allodinija and giperalgezija) educe. Advantage to the mentioned model is absence at the animal phenomena autotomii. A serious lack of the specified model is complexity of performance of such model, demanding special surgical technics and practice of performance of similar operations (Kim, Chung, 1992).

Model holodovogo damages (krionevroliza) a peripheral nerve. Within the first 7 days there are all basic signs of pain behaviour, and signs nejropaticheskoj pains and remain throughout 15-21 days. Advantage of this model is time damage of the excitatory frames that allows to study not only pain processes, but also processes of recover after damage of the excitatory frames (Kim et al., 1993).

Model pererezki a tail field of a spinal cord. At level othozhdenija S3 and S4 nerves carry out removal of a fragment of a spinal cord owing to what pain processes educe not on one of finitenesses, and in area nevrotomov, innervating a tail of an animal. Similar damage
Leads to occurrence mechanical allodinii, holodovoj and thermal giperalgezii. Advantage of this model is absence at the animal expressed pain behaviour, that allows to test an animal "blindly" (without knowledge of a damage place), reducing thereby probability of reception lozhnopolozhitelnyh results (Back et al., 2002; Na et al., 1994).

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Scientific source MALYSHKIN Andrey Anatolevich. ROLE of GLUTAMATERGICHESKY SYSTEM In PROCESSES of the SHARP And CHRONIC PAIN. The DISSERTATION on competition of a scientific degree of the candidate of medical sciences. St.-Petersburg 2006. 2006

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