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1.5.5. The means influencing a metabolism glutamata

Important part in function regulation glutamata in an organism are the factors which are responsible for its metabolism. So liberation oppression glutamata from presynaptic nerves is shown, that, bound to enzyme work glutamil karboksipeptidazy, responsible for synthesis glutamata from N - atsetilaspartilglutamata.

Depressing of activity of the given enzyme can render analgeticheskoe action without development of the characteristic by-effects arising at direct blockage glutamatnyh of receptors. Besides, N-atsetilaspartilglutamat shows abilities of the agonista/antagonist NMDA - retseptornogo a complex and co-operates with II bunch metabotropnyh receptors, that also can play an essential role in analgeticheskoj activity of a preparation (Bruno et al., 1998; Valivullah et al., 1994).

It is shown, that selective ingibitor the given enzyme 2-RMRA dozozavisimo depressed exhibitings nejropaticheskoj be ill rats (Chen et al., 2002), electrophysiological exhibitings allodinii (Pan et al., 2001), pain
Syndrome inflammatory geneza at rats (Yamamoto et al., 2001), but did not render influence on models of a sharp postoperative pain (Yamamoto et al., 2001). A number of works specifies that activity of this enzyme is important only at occurrence of various morbid conditions and has weak influence at healthy animals (Pan et al., 2001; Yamamoto et al., 2001).

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Thus, as a substantiation to application of antagonists of NMDA-receptors, and also the materials reacting on metabotropnye receptors and influencing a metabolism glutamata, as means of therapy of chronic pain syndromes ability to depress liberation processes glutamata from receptors at different levels can serve and to interfere with occurrence of a phenomenon of "inflation".

1.6

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Scientific source MALYSHKIN Andrey Anatolevich. ROLE of GLUTAMATERGICHESKY SYSTEM In PROCESSES of the SHARP And CHRONIC PAIN. The DISSERTATION on competition of a scientific degree of the candidate of medical sciences. St.-Petersburg 2006. 2006

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