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the Cellular mechanism of formation reparativnogo a dentine

In formation reparativnogo a dentine the important role is played by two kinds of cells of a pulp (Baume L.J., 1980). Pulpoblasty - cells similar to fibroblasts and fibrilloblasts. Not up to the end the mechanism of formation by fibrilloblasts peritubuljarnogo a dentine (Iwai-Liao Y is still clear., et al., 1992).

Nevertheless, it is known, that the new differentiation and the subsequent migration of fibrilloblasts from not differentiated ­ stvolovyh cells is possible (Sveen A.B., et al. 1968; Tziafas D.I., et al. 1990).

By results of researches T. Yamamura, spent in 1985, it is possible to make the conclusion, that the differentiation of new fibrilloblasts from originally not differentiated stvolovyh cells or other cells of a pulp can quite occur after an immediate covering of a pulp as isolating materials, and as a result of immediate entering into a dissected pulp cavity of adhesive systems.

New fibrilloblasts are formed from fibroblastopodobnyh cells which can be met in deeper layers of a pulp (Jin C., et al., 2000).

Some authors specify in necessity of presence of mineral components for a primary dentine for secondary formation of a tubular dentine (Tziafas D.I. et al., 1992). According to I. Thesleff (1986) cellular differentiation to fibrilloblasts occurs only at presence odontogeneticheskih epithelial micromorphological structures. At
certain circumstances there can be a replacement ­ fibroblastopodobnyh cells at the expense of these structures. Thereupon, the cellular matrix protein a fibronectin could have crucial importance in cellular processes of migration and differentiation (Kahler D.J., et al., 2013).

Under statement K.N. Yoshiba (1996), originally there could be one migration, adhesion and diffusion of fibroblasts to area of a line of demarcation mediated by a fibronectin.

the Similar mechanism of cellular differentiation is postulated for initial formation of a dentine during tooth development. Hence, indutsirovanie processes of cellular differentiation, migration and inquiry - tranenija fibrilloblasts occurs at the expense of the fibronectin which has been initially put in pawn in a basal membrane of primary fibrilloblasts (Yoshiba K.N. et al., 1996).

radiological research of tissues which opens possibility to estimate the processes occurring in tissues was carried out. Nevertheless, reliability of results at formation research «the dentinal bridge» is challenged (Qureshi A. E. S., 2014). In this case raised "porosity" of the neogenic dentine caused by punching channels of blood vessels and nervous fibers (Goldberg M is observed., et al. 1984; Cox

C. F., et al. 1996).

Authors (Kakarla P., et al., 2013) do not find out neogenic «the dentinal bridge», note only presence of appreciable changes in comparison with an intact primary dentine. Despite it, makroskopicheski the layer of a neodentine representing sufficient protection of a pulp from external stimuluses (Ahovuo-Saloranta A was defined., et al., 2013).

J.J. Jespersen with co-authors (2014) in researches of last years result data that at dentine caries there can be a microinflammatory process imperceptible at radiological research at a pulp.

According to some authors on reminiralizatsiju firm tissues of a tooth physical factors (Borisenko M. A, 2005) influence.

Recently in medical practice including in stomatology, wide application was found by the laser technics (Kita T., et al., 2014).

For activization of processes of a mineralization of a dentine a number of authors the method of deep fluorination and influence of physical factors, such as nizkointensivnoe consider possible to use laser radiation (Arcoria

C., 1995).

protivokariesnoe action nizkointensivnogo laser radiation develops of several components: immediate action on firm tissues of the tooth leading to change of permeability of an enamel, microhardness and remineralization intensifying; the mediated influence through a pulp of the tooth shown by stimulation of microcirculation and a metabolism, rising of activity of fibrilloblasts with formation of a replaceable dentine (Roeykens H., et al., 2004).

Laser radiation also has the general an effect, stimulating mechanisms of immune protection of the organism, leading mobilisation of the general adaptive reactions of an organism, normalising level of its homeostasis (Ivanov

A.S., 2000).

At the literature analysis it was possible to find out, that at treatment of deep caries the appreciable arsenal of medicinal preparations is used, but the most perspective are the substances providing a remineralization ­ of a dentine and stimulating odontotropnuju function of a pulp of a tooth. It is clinically confirmed (Moazzami F., et al., 2014), that at reliable isolation of a pulp from external pathological stimuluses favorable conditions for realisation of protective mechanisms of highly differentiated pulp are framed and, as a result, the high-grade fabric structures of a tooth stabilising the further development of caries and its complications are formed.

Nevertheless, in the literature there are no data on reception of prognostic signs of this or that outcome at treatment of deep caries, despite use of some diagnostic methods. In communication by it, and necessary creation experimental
models of caries of a dentine, a substantiation of a method of treatment of caries of a dentine on a teeth of laboratory animals with application of a method of deep fluorination of a dentine and laser therapy is actual enough.

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Scientific source KOVALEVA MARIA SERGEEVNA. Clinico-morphological research of a condition of tissues of a tooth at treatment of caries of a dentine with application of deep fluorination and nizkointensivnogo laser radiation. The dissertation on competition of a scientific degree of the candidate of medical sciences. Great Novgorod - & 2014. 2014

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